ENSMUSG00000021838


Mus musculus

Features
Gene ID: ENSMUSG00000021838
  
Biological name :Samd4
  
Synonyms : 1 / Q8CBY1 / Samd4
  
Possible biological names infered from orthology : Q9UPU9 / SAMD4A / sterile alpha motif domain containing 4A
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C1
Gene start: 46882854
Gene end: 47105815
  
Corresponding Affymetrix probe sets: 10414333 (MoGene1.0st)   1424594_at (Mouse Genome 430 2.0 Array)   1429449_at (Mouse Genome 430 2.0 Array)   1436356_at (Mouse Genome 430 2.0 Array)   1454382_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154727
Ensembl peptide - ENSMUSP00000098237
Ensembl peptide - ENSMUSP00000114621
Ensembl peptide - ENSMUSP00000115569
Ensembl peptide - ENSMUSP00000022386
Ensembl peptide - ENSMUSP00000122833
Ensembl peptide - ENSMUSP00000153846
NCBI entrez gene - 74480     See in Manteia.
MGI - MGI:1921730
RefSeq - XM_006519631
RefSeq - NM_001037221
RefSeq - NM_001163433
RefSeq - NM_001310544
RefSeq - NM_028966
RefSeq - XM_006519627
RefSeq - XM_006519628
RefSeq Peptide - NP_083242
RefSeq Peptide - NP_001032298
RefSeq Peptide - NP_001156905
RefSeq Peptide - NP_001297473
swissprot - Q8CBY1
Ensembl - ENSMUSG00000021838
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 samd4aENSDARG00000075759Danio rerio
 SAMD4AENSGALG00000041790Gallus gallus
 Q9UPU9ENSG00000020577Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Samd4b / sterile alpha motif domain containing 4B / Q5PRF9*ENSMUSG0000010933660


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR037093  Smaug, PHAT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IBA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0017148 negative regulation of translation IBA
 biological_processGO:0043488 regulation of mRNA stability IBA
 biological_processGO:0045727 positive regulation of translation ISO
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030371 translation repressor activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Mbpshi-J/Mbpshi-J
Genetic Background: BALB/cJ-Mbpshi-J/GrsrJ

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mbpshi-J/Mbpshi-J
Genetic Background: BALB/cJ-Mbpshi-J/GrsrJ

Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0000734 muscle hypoplasia "underdevelopment or atrophy of muscle" [J:15108]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl5tm1.1Mkch/Cxcl5tm1.1Mkch
Genetic Background: B6.129P2-Cxcl5tm1.1Mkch

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cxcl5tm1.1Mkch/Cxcl5tm1.1Mkch
Genetic Background: B6.129P2-Cxcl5tm1.1Mkch

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cxcl5tm1.1Mkch/Cxcl5tm1.1Mkch
Genetic Background: B6.129P2-Cxcl5tm1.1Mkch

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Mbpshi-J/Mbpshi-J
Genetic Background: BALB/cJ-Mbpshi-J/GrsrJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl5tm1.1Mkch/Cxcl5tm1.1Mkch
Genetic Background: B6.129P2-Cxcl5tm1.1Mkch

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl5tm1.1Mkch/Cxcl5tm1.1Mkch
Genetic Background: B6.129P2-Cxcl5tm1.1Mkch

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0005451 abnormal body composition "anomalous relative amounts of various components of the body, such as percent body fat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0009117 abnormal white fat cell morphology "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0010399 decreased skeletal muscle glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

 MP:0010934 increased subcutaneous adipose tissue amount "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Samd4m1Btlr/Samd4m1Btlr
Genetic Background: C57BL/6J-Samd4m1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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