ENSMUSG00000022747


Mus musculus

Features
Gene ID: ENSMUSG00000022747
  
Biological name :St3gal6
  
Synonyms : Mus musculus ST3 beta-galactoside alpha-2,3-sialyltransferase 6 (St3gal6), transcript variant 2, mRNA. / Q8VIB3 / St3gal6
  
Possible biological names infered from orthology : Q9Y274 / ST3 beta-galactoside alpha-2,3-sialyltransferase 6
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C1.2
Gene start: 58468125
Gene end: 58524243
  
Corresponding Affymetrix probe sets: 10440099 (MoGene1.0st)   1443740_at (Mouse Genome 430 2.0 Array)   1447841_x_at (Mouse Genome 430 2.0 Array)   1449078_at (Mouse Genome 430 2.0 Array)   1449079_s_at (Mouse Genome 430 2.0 Array)   1454246_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109997
Ensembl peptide - ENSMUSP00000115756
Ensembl peptide - ENSMUSP00000116202
Ensembl peptide - ENSMUSP00000117849
Ensembl peptide - ENSMUSP00000109998
NCBI entrez gene - 54613     See in Manteia.
MGI - MGI:1888707
RefSeq - XM_017317085
RefSeq - XM_011245973
RefSeq - XM_011245974
RefSeq - XM_011245975
RefSeq - XM_011245976
RefSeq - XM_017317083
RefSeq - XM_017317084
RefSeq - NM_001357433
RefSeq - NM_018784
RefSeq - XM_006522387
RefSeq - XM_006522388
RefSeq - XM_011245971
RefSeq - XM_011245972
RefSeq Peptide - NP_001344362
RefSeq Peptide - NP_001344364
RefSeq Peptide - NP_061254
swissprot - A6X953
swissprot - Q8VIB3
swissprot - A6X952
Ensembl - ENSMUSG00000022747
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ST3GAL6ENSGALG00000015252Gallus gallus
 Q9Y274ENSG00000064225Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P97325 / St3gal3 / CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase / Q11203* / ST3 beta-galactoside alpha-2,3-sialyltransferase 3*ENSMUSG0000002853836
Q91Y74 / St3gal4 / ST3 beta-galactoside alpha-2,3-sialyltransferase 4 / Q11206*ENSMUSG0000003203833
O88829 / St3gal5 / Lactosylceramide alpha-2,3-sialyltransferase / Q9UNP4* / ST3 beta-galactoside alpha-2,3-sialyltransferase 5*ENSMUSG0000005609131
P54751 / St3gal1 / ST3 beta-galactoside alpha-2,3-sialyltransferase 1 / Q11201*ENSMUSG0000001384623
Q11204 / St3gal2 / CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 / Q16842* / ST3 beta-galactoside alpha-2,3-sialyltransferase 2*ENSMUSG0000003174919
P70277 / St6galnac2 / ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 / Q9UJ37* / ST6 N-acetylgalactosaminide alpha-2,6-sialylt...ENSMUSG0000005728619
Q9QZ39 / St6galnac1 / Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 / Q9NSC7* / ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1*ENSMUSG0000000958818


Protein motifs (from Interpro)
Interpro ID Name
 IPR001675  Glycosyl transferase family 29
 IPR012163  Sialyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process ISS
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006664 glycolipid metabolic process ISO
 biological_processGO:0009311 oligosaccharide metabolic process ISS
 biological_processGO:0018279 protein N-linked glycosylation via asparagine IBA
 biological_processGO:0071354 cellular response to interleukin-6 ISS
 biological_processGO:0097503 sialylation IEA
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008373 sialyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity ISO


Pathways (from Reactome)
Pathway description
Keratan sulfate biosynthesis
Sialic acid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm,St3gal6tm1.1Jxm/St3gal6tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm,St3gal6tm1.1Jxm/St3gal6tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm,St3gal6tm1.1Jxm/St3gal6tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm,St3gal6tm1.1Jxm/St3gal6tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpr68tm1.1Aha/Gpr68tm1.1Aha
Genetic Background: B6.129(C)-Gpr68tm1.1Aha

Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm,St3gal6tm1.1Jxm/St3gal6tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Gpr68tm1.1Aha/Gpr68tm1.1Aha
Genetic Background: B6.129(C)-Gpr68tm1.1Aha

Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm,St3gal6tm1.1Jxm/St3gal6tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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