ENSMUSG00000031749


Mus musculus

Features
Gene ID: ENSMUSG00000031749
  
Biological name :St3gal2
  
Synonyms : CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 / Q11204 / St3gal2
  
Possible biological names infered from orthology : Q16842 / ST3 beta-galactoside alpha-2,3-sialyltransferase 2
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 110919922
Gene end: 110972480
  
Corresponding Affymetrix probe sets: 10575534 (MoGene1.0st)   1421890_at (Mouse Genome 430 2.0 Array)   1421891_at (Mouse Genome 430 2.0 Array)   1421892_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034197
Ensembl peptide - ENSMUSP00000113900
NCBI entrez gene - 20444     See in Manteia.
MGI - MGI:99427
RefSeq - XM_017312624
RefSeq - NM_009179
RefSeq - XM_006530786
RefSeq - XM_006530787
RefSeq - XM_006530788
RefSeq Peptide - NP_033205
swissprot - Q11204
swissprot - D3Z3V2
Ensembl - ENSMUSG00000031749
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 st3gal2ENSDARG00000112898Danio rerio
 ST3GAL2ENSGALG00000002651Gallus gallus
 Q16842ENSG00000157350Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P54751 / St3gal1 / ST3 beta-galactoside alpha-2,3-sialyltransferase 1 / Q11201*ENSMUSG0000001384647
P70277 / St6galnac2 / ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 / Q9UJ37* / ST6 N-acetylgalactosaminide alpha-2,6-sialylt...ENSMUSG0000005728623
Q91Y74 / St3gal4 / ST3 beta-galactoside alpha-2,3-sialyltransferase 4 / Q11206*ENSMUSG0000003203822
Q9QZ39 / St6galnac1 / Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 / Q9NSC7* / ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1*ENSMUSG0000000958821
P97325 / St3gal3 / CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase / Q11203* / ST3 beta-galactoside alpha-2,3-sialyltransferase 3*ENSMUSG0000002853821
O88829 / St3gal5 / Lactosylceramide alpha-2,3-sialyltransferase / Q9UNP4* / ST3 beta-galactoside alpha-2,3-sialyltransferase 5*ENSMUSG0000005609120
Q8VIB3 / St3gal6 / Mus musculus ST3 beta-galactoside alpha-2,3-sialyltransferase 6 (St3gal6), transcript variant 2, mRNA. / Q9Y274* / ST3 beta-galactoside alpha-2,3-sialyltransferase 6*ENSMUSG0000002274718


Protein motifs (from Interpro)
Interpro ID Name
 IPR001675  Glycosyl transferase family 29
 IPR012163  Sialyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation ISO
 biological_processGO:0009101 glycoprotein biosynthetic process IEA
 biological_processGO:0009247 glycolipid biosynthetic process IEA
 biological_processGO:0009311 oligosaccharide metabolic process IBA
 biological_processGO:0009312 oligosaccharide biosynthetic process IEA
 biological_processGO:0018279 protein N-linked glycosylation via asparagine IBA
 biological_processGO:0030259 lipid glycosylation IEA
 biological_processGO:0097503 sialylation IEA
 biological_processGO:1990743 protein sialylation IEA
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 molecular_functionGO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
 molecular_functionGO:0008373 sialyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0047288 monosialoganglioside sialyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Keratan sulfate biosynthesis
Sialic acid metabolism
Termination of O-glycan biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chst3tm1Tmu/Chst3tm1Tmu
Genetic Background: involves: 129S2/SvPas

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Chst3tm1Tmu/Chst3tm1Tmu
Genetic Background: involves: 129S2/SvPas

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Chst3tm1Tmu/Chst3tm1Tmu
Genetic Background: involves: 129S2/SvPas

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Chst3tm1Tmu/Chst3tm1Tmu
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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