ENSMUSG00000032038


Mus musculus

Features
Gene ID: ENSMUSG00000032038
  
Biological name :St3gal4
  
Synonyms : Q91Y74 / ST3 beta-galactoside alpha-2,3-sialyltransferase 4 / St3gal4
  
Possible biological names infered from orthology : Q11206
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A4
Gene start: 35046576
Gene end: 35119268
  
Corresponding Affymetrix probe sets: 10592084 (MoGene1.0st)   1425668_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034537
Ensembl peptide - ENSMUSP00000150841
Ensembl peptide - ENSMUSP00000150775
Ensembl peptide - ENSMUSP00000150423
Ensembl peptide - ENSMUSP00000150187
Ensembl peptide - ENSMUSP00000149827
Ensembl peptide - ENSMUSP00000149489
Ensembl peptide - ENSMUSP00000149302
Ensembl peptide - ENSMUSP00000149145
NCBI entrez gene - 20443     See in Manteia.
MGI - MGI:1316743
RefSeq - XM_011242433
RefSeq - XM_011242432
RefSeq - XM_011242429
RefSeq - XM_006510113
RefSeq - XM_006510112
RefSeq - XM_006510111
RefSeq - XM_006510110
RefSeq - NM_009178
RefSeq - XM_006510108
RefSeq - XM_006510109
RefSeq Peptide - NP_033204
swissprot - Q91Y74
swissprot - A0A1L1SUM8
swissprot - A0A1L1SQQ6
swissprot - A0A1L1SR32
swissprot - A0A1L1SRJ3
swissprot - A0A1L1SSB1
swissprot - A0A1L1ST66
swissprot - A0A1L1STP4
swissprot - A0A1L1SUJ7
Ensembl - ENSMUSG00000032038
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 st3gal4ENSDARG00000041006Danio rerio
 ST3GAL4ENSGALG00000029747Gallus gallus
 Q11206ENSG00000110080Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P97325 / St3gal3 / CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase / Q11203* / ST3 beta-galactoside alpha-2,3-sialyltransferase 3*ENSMUSG0000002853837
Q8VIB3 / St3gal6 / Mus musculus ST3 beta-galactoside alpha-2,3-sialyltransferase 6 (St3gal6), transcript variant 2, mRNA. / Q9Y274* / ST3 beta-galactoside alpha-2,3-sialyltransferase 6*ENSMUSG0000002274732
O88829 / St3gal5 / Lactosylceramide alpha-2,3-sialyltransferase / Q9UNP4* / ST3 beta-galactoside alpha-2,3-sialyltransferase 5*ENSMUSG0000005609131
Q11204 / St3gal2 / CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 / Q16842* / ST3 beta-galactoside alpha-2,3-sialyltransferase 2*ENSMUSG0000003174923
P54751 / St3gal1 / ST3 beta-galactoside alpha-2,3-sialyltransferase 1 / Q11201*ENSMUSG0000001384623
Q9QZ39 / St6galnac1 / Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 / Q9NSC7* / ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1*ENSMUSG0000000958822
P70277 / St6galnac2 / ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 / Q9UJ37* / ST6 N-acetylgalactosaminide alpha-2,6-sialylt...ENSMUSG0000005728621


Protein motifs (from Interpro)
Interpro ID Name
 IPR001675  Glycosyl transferase family 29
 IPR012163  Sialyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0009101 glycoprotein biosynthetic process IEA
 biological_processGO:0009247 glycolipid biosynthetic process IEA
 biological_processGO:0009311 oligosaccharide metabolic process IBA
 biological_processGO:0009312 oligosaccharide biosynthetic process IEA
 biological_processGO:0018279 protein N-linked glycosylation via asparagine IBA
 biological_processGO:0030259 lipid glycosylation IEA
 biological_processGO:0050890 cognition IEA
 biological_processGO:0097503 sialylation IEA
 biological_processGO:1990743 protein sialylation IEA
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 molecular_functionGO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA
 molecular_functionGO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity IEA
 molecular_functionGO:0008373 sialyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0047288 monosialoganglioside sialyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Keratan sulfate biosynthesis
Sialic acid metabolism
N-Glycan antennae elongation
Termination of O-glycan biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Pmm2tm1.1Jins/Pmm2tm2.1Jins
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001500 reduced kindling behavior "fewer epileptic episodes induced by daily sub threshold electrical brain stimulation" [J:45446]
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Allelic Composition: Pmm2tm1.1Jins/Pmm2tm2.1Jins
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pmm2tm1.1Jins/Pmm2tm2.1Jins
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Pmm2tm1.1Jins/Pmm2tm2.1Jins
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Gpr68tm1.1Aha/Gpr68tm1.1Aha
Genetic Background: B6.129(C)-Gpr68tm1.1Aha

Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm,St3gal6tm1.1Jxm/St3gal6tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002806 abnormal conditioned emotional response "defects in an emotional response that has been acquired by conditioning " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Pmm2tm1.1Jins/Pmm2tm2.1Jins
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
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Allelic Composition: Pmm2tm1.1Jins/Pmm2tm2.1Jins
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Gpr68tm1.1Aha/Gpr68tm1.1Aha
Genetic Background: B6.129(C)-Gpr68tm1.1Aha

Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm,St3gal6tm1.1Jxm/St3gal6tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm,St3gal6tm1.1Jxm/St3gal6tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003459 increased fear-related response "greater emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Pmm2tm1.1Jins/Pmm2tm2.1Jins
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003627 abnormal lymphocyte rolling "anomaly in the number or velocity of lymphocytes rolling along the luminal aspects of high endothelial venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpr68tm1.1Aha/Gpr68tm1.1Aha
Genetic Background: B6.129(C)-Gpr68tm1.1Aha

Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm,St3gal6tm1.1Jxm/St3gal6tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pmm2tm1.1Jins/Pmm2tm2.1Jins
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Tnnt2tm2Mmto/Tnnt2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm,St3gal6tm1.1Jxm/St3gal6tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008831 abnormal insulin-like growth factor I level "aomaly in the concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MESH:D12.644.276.937.400, MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Pmm2tm1.1Jins/Pmm2tm2.1Jins
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0012286 decreased frequency of paradoxical sleep "decreased incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Pmm2tm1.1Jins/Pmm2tm2.1Jins
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: St3gal4tm1.1Jxm/St3gal4tm1.1Jxm,St3gal6tm1.1Jxm/St3gal6tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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