ENSMUSG00000056091


Mus musculus

Features
Gene ID: ENSMUSG00000056091
  
Biological name :St3gal5
  
Synonyms : Lactosylceramide alpha-2,3-sialyltransferase / O88829 / St3gal5
  
Possible biological names infered from orthology : Q9UNP4 / ST3 beta-galactoside alpha-2,3-sialyltransferase 5
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 72097592
Gene end: 72154571
  
Corresponding Affymetrix probe sets: 10539080 (MoGene1.0st)   1449198_a_at (Mouse Genome 430 2.0 Array)   1460241_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145599
Ensembl peptide - ENSMUSP00000146063
Ensembl peptide - ENSMUSP00000070414
Ensembl peptide - ENSMUSP00000109747
NCBI entrez gene - 20454     See in Manteia.
MGI - MGI:1339963
RefSeq - XM_017321473
RefSeq - NM_011375
RefSeq - XM_006505816
RefSeq - XM_006505817
RefSeq - XM_006505818
RefSeq - XM_006505819
RefSeq - XM_006505820
RefSeq - NM_001035228
RefSeq Peptide - NP_001030305
RefSeq Peptide - NP_035505
swissprot - A0A0U1RPP1
swissprot - A0A0U1RNK2
swissprot - O88829
swissprot - A0A0R4J1J3
Ensembl - ENSMUSG00000056091
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 st3gal5ENSDARG00000037556Danio rerio
 ST3GAL5ENSGALG00000033260Gallus gallus
 Q9UNP4ENSG00000115525Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P97325 / St3gal3 / CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase / Q11203* / ST3 beta-galactoside alpha-2,3-sialyltransferase 3*ENSMUSG0000002853831
Q91Y74 / St3gal4 / ST3 beta-galactoside alpha-2,3-sialyltransferase 4 / Q11206*ENSMUSG0000003203825
Q8VIB3 / St3gal6 / Mus musculus ST3 beta-galactoside alpha-2,3-sialyltransferase 6 (St3gal6), transcript variant 2, mRNA. / Q9Y274* / ST3 beta-galactoside alpha-2,3-sialyltransferase 6*ENSMUSG0000002274725
Q9QZ39 / St6galnac1 / Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 / Q9NSC7* / ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1*ENSMUSG0000000958818
Q11204 / St3gal2 / CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 / Q16842* / ST3 beta-galactoside alpha-2,3-sialyltransferase 2*ENSMUSG0000003174917
P54751 / St3gal1 / ST3 beta-galactoside alpha-2,3-sialyltransferase 1 / Q11201*ENSMUSG0000001384617
P70277 / St6galnac2 / ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 / Q9UJ37* / ST6 N-acetylgalactosaminide alpha-2,6-sialylt...ENSMUSG0000005728616


Protein motifs (from Interpro)
Interpro ID Name
 IPR001675  Glycosyl transferase family 29
 IPR012163  Sialyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0009311 oligosaccharide metabolic process IBA
 biological_processGO:0018279 protein N-linked glycosylation via asparagine IBA
 biological_processGO:0097503 sialylation IEA
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008373 sialyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity ISO


Pathways (from Reactome)
Pathway description
Sialic acid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0004494 abnormal synaptic glutamate release "aberrant secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fermt3tm1.1Efp/Fermt3tm1.1Efp
Genetic Background: involves: C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0009765 abnormal xenobiotic induced morbidity/mortality "any anomaly in induction of a diseased state or death caused by a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fermt3tm1.1Efp/Fermt3tm1.1Efp
Genetic Background: involves: C57BL/6

 MP:0020194 abnormal glycosphingolipid level "any anomaly in the concentrations of glycosphingolipids, a subtype of glycolipids containing the amino alcohol sphingosine, in the body" [GOC:NV, http://en.wikipedia.org/wiki/Glycosphingolipid]
Show

Allelic Composition: Fermt3tm1.1Efp/Fermt3tm1.1Efp
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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