ENSMUSG00000022788


Mus musculus

Features
Gene ID: ENSMUSG00000022788
  
Biological name :Fgd4
  
Synonyms : Fgd4 / FYVE, RhoGEF and PH domain-containing protein 4 / Q91ZT5
  
Possible biological names infered from orthology : FYVE, RhoGEF and PH domain containing 4 / Q96M96
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A3
Gene start: 16416917
Gene end: 16600549
  
Corresponding Affymetrix probe sets: 10438017 (MoGene1.0st)   1425037_at (Mouse Genome 430 2.0 Array)   1426041_a_at (Mouse Genome 430 2.0 Array)   1426042_at (Mouse Genome 430 2.0 Array)   1451659_at (Mouse Genome 430 2.0 Array)   1455337_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123763
Ensembl peptide - ENSMUSP00000125649
Ensembl peptide - ENSMUSP00000125736
Ensembl peptide - ENSMUSP00000069573
Ensembl peptide - ENSMUSP00000125174
NCBI entrez gene - 224014     See in Manteia.
MGI - MGI:2183747
RefSeq - XM_011245874
RefSeq - NM_139232
RefSeq - XM_006522023
RefSeq - XM_006522024
RefSeq - XM_006522025
RefSeq - XM_006522027
RefSeq - XM_006522029
RefSeq - NM_001301817
RefSeq - NM_001301818
RefSeq Peptide - NP_631978
RefSeq Peptide - NP_001288746
RefSeq Peptide - NP_001288747
swissprot - F8WGX0
swissprot - Q91ZT5
swissprot - E0CZ69
Ensembl - ENSMUSG00000022788
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgd4aENSDARG00000101471Danio rerio
 fgd4bENSDARG00000060248Danio rerio
 FGD4ENSGALG00000012932Gallus gallus
 FGD4ENSG00000139132Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgd1 / P52734 / FYVE, RhoGEF and PH domain-containing protein 1 / P98174* / FYVE, RhoGEF and PH domain containing 1*ENSMUSG0000002526545
Fgd2 / Q8BY35 / FYVE, RhoGEF and PH domain-containing protein 2 / Q7Z6J4* / FYVE, RhoGEF and PH domain containing 2*ENSMUSG0000002401339
Fgd3 / FYVE, RhoGEF and PH domain containing 3 / Q5JSP0*ENSMUSG0000003794636
Fgd6 / Q69ZL1 / FYVE, RhoGEF and PH domain-containing protein 6 / Q6ZV73* / FYVE, RhoGEF and PH domain containing 6*ENSMUSG0000002002126
Fgd5 / FYVE, RhoGEF and PH domain containing 5 / Q6ZNL6*ENSMUSG0000003403723
Q3TB82 / Plekhf1 / Pleckstrin homology domain-containing family F member 1 / Q96S99* / pleckstrin homology and FYVE domain containing 1*ENSMUSG000000741709
Q91WB4 / Plekhf2 / Pleckstrin homology domain-containing family F member 2 / Q9H8W4* / pleckstrin homology and FYVE domain containing 2*ENSMUSG000000499698


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000306  FYVE zinc finger
 IPR001849  Pleckstrin homology domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR017455  Zinc finger, FYVE-related
 IPR035899  Dbl homology (DH) domain superfamily
 IPR035941  FGD1-4, C-terminal PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007257 activation of JUN kinase activity ISO
 biological_processGO:0030032 lamellipodium assembly IDA
 biological_processGO:0030035 microspike assembly IDA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

Allelic Composition: Fgd4tm1Ics/Fgd4tm1Ics,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: FVB/N

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

Allelic Composition: Fgd4tm1Ics/Fgd4tm1Ics,Tg(Plp1-cre/ERT2)1Ueli/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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