MP:0000183 | decreased circulating LDL cholesterol level | "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * DBA
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MP:0000186 | decreased circulating HDL cholesterol level | "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ace2tm1Pngr/Y,Pik3cgtm1Pngr/Pik3cgtm1Pngr Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002647 | decreased cholesterol absorption | "reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * DBA
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MP:0002942 | decreased circulating alanine transaminase level | "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * DBA
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MP:0003868 | abnormal feces composition | "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * DBA
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MP:0003982 | increased cholesterol level | "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * DBA
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MP:0005146 | decreased circulating VLDL cholesterol level | "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * DBA
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MP:0005179 | decreased total circulating cholesterol level | "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
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MP:0005341 | decreased susceptibility to atherosclerosis | "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
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MP:0005365 | abnormal bile salt homeostasis | "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
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MP:0005632 | decreased circulating aspartate transaminase level | "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * DBA
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MP:0010027 | increased liver cholesterol level | "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * DBA
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MP:0012338 | decreased bile salt level | "reduced level of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith] |
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Allelic Composition: Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: C57BL/6 * DBA
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