ENSMUSG00000023906


Mus musculus

Features
Gene ID: ENSMUSG00000023906
  
Biological name :Cldn6
  
Synonyms : Claudin-6 / Cldn6 / Q9Z262
  
Possible biological names infered from orthology : P56747
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 23679365
Gene end: 23682446
  
Corresponding Affymetrix probe sets: 10442327 (MoGene1.0st)   1417845_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024699
NCBI entrez gene - 54419     See in Manteia.
MGI - MGI:1859284
RefSeq - XM_006524641
RefSeq - NM_018777
RefSeq Peptide - NP_061247
swissprot - Q0GH64
swissprot - Q9Z262
Ensembl - ENSMUSG00000023906
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CLDN6ENSG00000184697Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cldn9 / Q9Z0S7 / Claudin-9 / O95484*ENSMUSG0000006672070
Cldn4 / O35054 / Claudin-4 / O14493*ENSMUSG0000004750159
Cldn3 / Q9Z0G9 / Claudin-3 / O15551*ENSMUSG0000007047358
Cldn5 / O54942 / Claudin-5 / O00501*ENSMUSG0000004137851
Cldn1 / O88551 / Claudin-1 / O95832*ENSMUSG0000002251247
Cldn8 / Q9Z260 / Claudin-8 / P56748*ENSMUSG0000005052044
Cldn7 / Q9Z261 / Claudin-7 / O95471*ENSMUSG0000001856943
Cldn19 / Q9ET38 / Claudin-19 / Q8N6F1*ENSMUSG0000006605841
Cldn14 / Q9Z0S3 / Claudin-14 / O95500*ENSMUSG0000004710941
Cldn2 / O88552 / Claudin-2 / P57739*ENSMUSG0000004723037


Protein motifs (from Interpro)
Interpro ID Name
 IPR003925  Claudin-6
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 biological_processGO:0045216 cell-cell junction organization IDA
 biological_processGO:0046718 viral entry into host cell IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0016327 apicolateral plasma membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
Show

Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Atp7atm1.1Mjp/Y,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Atp7atm1.1Mjp/Y,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/Gt(ROSA)26Sortm1(SNCA*A53T)Djmo
Genetic Background: involves: 129 * C57BL/6J

 MP:0002861 abnormal tail bud morphology "anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp7atm1.1Mjp/Y,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atp7atm1.1Mjp/Y,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0009901 abnormal frontonasal prominence morphology "any structural anomaly of an unpaired facial process in the embryo formed from the tissues surrounding the forebrain vesicle that develops into the forehead and bridge of the nose/snout" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Atp7atm1.1Mjp/Y,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Atp7atm1.1Mjp/Y,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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