ENSMUSG00000018569


Mus musculus

Features
Gene ID: ENSMUSG00000018569
  
Biological name :Cldn7
  
Synonyms : Claudin-7 / Cldn7 / Q9Z261
  
Possible biological names infered from orthology : O95471
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 69964779
Gene end: 69967885
  
Corresponding Affymetrix probe sets: 10377673 (MoGene1.0st)   1448393_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104237
Ensembl peptide - ENSMUSP00000137627
Ensembl peptide - ENSMUSP00000104238
Ensembl peptide - ENSMUSP00000018713
Ensembl peptide - ENSMUSP00000090725
NCBI entrez gene - 53624     See in Manteia.
MGI - MGI:1859285
RefSeq - NM_016887
RefSeq - NM_001193619
RefSeq Peptide - NP_001180548
RefSeq Peptide - NP_058583
swissprot - Q9Z261
swissprot - B1AR46
swissprot - J3QQ48
swissprot - B1AR47
Ensembl - ENSMUSG00000018569
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cldn7aENSDARG00000036376Danio rerio
 cldn7bENSDARG00000014047Danio rerio
 CLDN7ENSG00000181885Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cldn1 / O88551 / Claudin-1 / O95832*ENSMUSG0000002251260
Cldn19 / Q9ET38 / Claudin-19 / Q8N6F1*ENSMUSG0000006605854
Cldn4 / O35054 / Claudin-4 / O14493*ENSMUSG0000004750150
Cldn3 / Q9Z0G9 / Claudin-3 / O15551*ENSMUSG0000007047348
Cldn9 / Q9Z0S7 / Claudin-9 / O95484*ENSMUSG0000006672046
Cldn6 / Q9Z262 / Claudin-6 / P56747*ENSMUSG0000002390645
Cldn14 / Q9Z0S3 / Claudin-14 / O95500*ENSMUSG0000004710945
Cldn5 / O54942 / Claudin-5 / O00501*ENSMUSG0000004137843
Cldn8 / Q9Z260 / Claudin-8 / P56748*ENSMUSG0000005052042
Cldn2 / O88552 / Claudin-2 / P57739*ENSMUSG0000004723037


Protein motifs (from Interpro)
Interpro ID Name
 IPR003552  Claudin-7
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 biological_processGO:0032463 negative regulation of protein homooligomerization IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:2000147 positive regulation of cell motility IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane IDA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISS
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0011459 increased urine chloride ion level "abnormally large amounts of chloride ion in the urine" [MGI:csmith]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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