ENSMUSG00000041378


Mus musculus

Features
Gene ID: ENSMUSG00000041378
  
Biological name :Cldn5
  
Synonyms : Claudin-5 / Cldn5 / O54942
  
Possible biological names infered from orthology : O00501
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 18776847
Gene end: 18778260
  
Corresponding Affymetrix probe sets: 10434229 (MoGene1.0st)   1417839_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041925
NCBI entrez gene - 12741     See in Manteia.
MGI - MGI:1276112
RefSeq - NM_013805
RefSeq Peptide - NP_038833
swissprot - O54942
Ensembl - ENSMUSG00000041378
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cldn5aENSDARG00000043716Danio rerio
 cldn5bENSDARG00000014059Danio rerio
 CLDN5ENSGALG00000001621Gallus gallus
 CLDN5ENSG00000184113Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cldn9 / Q9Z0S7 / Claudin-9 / O95484*ENSMUSG0000006672052
Cldn6 / Q9Z262 / Claudin-6 / P56747*ENSMUSG0000002390651
Cldn3 / Q9Z0G9 / Claudin-3 / O15551*ENSMUSG0000007047350
Cldn4 / O35054 / Claudin-4 / O14493*ENSMUSG0000004750148
Cldn7 / Q9Z261 / Claudin-7 / O95471*ENSMUSG0000001856942
Cldn8 / Q9Z260 / Claudin-8 / P56748*ENSMUSG0000005052041
Cldn1 / O88551 / Claudin-1 / O95832*ENSMUSG0000002251241
Cldn14 / Q9Z0S3 / Claudin-14 / O95500*ENSMUSG0000004710940
Cldn19 / Q9ET38 / Claudin-19 / Q8N6F1*ENSMUSG0000006605840
Cldn2 / O88552 / Claudin-2 / P57739*ENSMUSG0000004723032


Protein motifs (from Interpro)
Interpro ID Name
 IPR003551  Claudin-5
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007043 cell-cell junction assembly ISO
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 biological_processGO:0042552 myelination IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0098609 cell-cell adhesion IC
 biological_processGO:1903142 positive regulation of establishment of endothelial barrier ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction ISO
 cellular_componentGO:0005923 bicellular tight junction ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane ISO
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton ISO
 cellular_componentGO:0033270 paranode region of axon IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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