ENSG00000184113


Homo sapiens

Features
Gene ID: ENSG00000184113
  
Biological name :CLDN5
  
Synonyms : claudin 5 / CLDN5 / O00501
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q11.21
Gene start: 19523024
Gene end: 19527545
  
Corresponding Affymetrix probe sets: 204482_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480623
Ensembl peptide - ENSP00000384554
Ensembl peptide - ENSP00000385477
Ensembl peptide - ENSP00000400612
NCBI entrez gene - 7122     See in Manteia.
OMIM - 602101
RefSeq - XM_017028930
RefSeq - NM_001130861
RefSeq - NM_003277
RefSeq - XM_017028929
RefSeq Peptide - NP_003268
RefSeq Peptide - NP_001124333
swissprot - O00501
swissprot - D3DX19
Ensembl - ENSG00000184113
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cldn5aENSDARG00000043716Danio rerio
 cldn5bENSDARG00000014059Danio rerio
 CLDN5ENSGALG00000001621Gallus gallus
 Cldn5ENSMUSG00000041378Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLDN9 / O95484 / claudin 9ENSG0000021393738
CLDN6 / P56747 / claudin 6ENSG0000018469738
CLDN3 / O15551 / claudin 3ENSG0000016521538
CLDN4 / O14493 / claudin 4ENSG0000018914333
CLDN1 / O95832 / claudin 1ENSG0000016334732
CLDN7 / O95471 / claudin 7ENSG0000018188530
CLDN19 / Q8N6F1 / claudin 19ENSG0000016400729
CLDN8 / P56748 / claudin 8ENSG0000015628429
CLDN14 / O95500 / claudin 14ENSG0000015926128
CLDN2 / P57739 / claudin 2ENSG0000016537624


Protein motifs (from Interpro)
Interpro ID Name
 IPR003551  Claudin-5
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003151 outflow tract morphogenesis TAS
 biological_processGO:0007043 cell-cell junction assembly IMP
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0007612 learning TAS
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 biological_processGO:0042552 myelination IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0060021 roof of mouth development TAS
 biological_processGO:0060325 face morphogenesis TAS
 biological_processGO:1903142 positive regulation of establishment of endothelial barrier IMP
 biological_processGO:2000810 regulation of bicellular tight junction assembly TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane IDA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 cellular_componentGO:0033270 paranode region of axon IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
Tight junction interactions
RUNX1 regulates expression of components of tight junctions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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