ENSG00000189143


Homo sapiens

Features
Gene ID: ENSG00000189143
  
Biological name :CLDN4
  
Synonyms : claudin 4 / CLDN4 / O14493
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q11.23
Gene start: 73799542
Gene end: 73832693
  
Corresponding Affymetrix probe sets: 1569421_at (Human Genome U133 Plus 2.0 Array)   201428_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388639
Ensembl peptide - ENSP00000409544
Ensembl peptide - ENSP00000342445
NCBI entrez gene - 1364     See in Manteia.
OMIM - 602909
RefSeq - NM_001305
RefSeq Peptide - NP_001296
swissprot - O14493
swissprot - Q75L80
Ensembl - ENSG00000189143
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cldnaENSDARG00000069888Danio rerio
 cldnbENSDARG00000009544Danio rerio
 cldncENSDARG00000015955Danio rerio
 cldndENSDARG00000006580Danio rerio
 cldneENSDARG00000043128Danio rerio
 cldnfENSDARG00000043133Danio rerio
 cldngENSDARG00000003701Danio rerio
 cldnhENSDARG00000069503Danio rerio
 zgc:112437ENSDARG00000009215Danio rerio
 zgc:136892ENSDARG00000069505Danio rerio
 Cldn4ENSMUSG00000047501Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLDN3 / O15551 / claudin 3ENSG0000016521571
CLDN9 / O95484 / claudin 9ENSG0000021393764
CLDN6 / P56747 / claudin 6ENSG0000018469762
CLDN1 / O95832 / claudin 1ENSG0000016334747
CLDN5 / O00501 / claudin 5ENSG0000018411347
CLDN14 / O95500 / claudin 14ENSG0000015926145
CLDN8 / P56748 / claudin 8ENSG0000015628444
CLDN7 / O95471 / claudin 7ENSG0000018188544
CLDN19 / Q8N6F1 / claudin 19ENSG0000016400743
CLDN2 / P57739 / claudin 2ENSG0000016537640


Protein motifs (from Interpro)
Interpro ID Name
 IPR003550  Claudin-4
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0061436 establishment of skin barrier IMP
 biological_processGO:0070293 renal absorption ISS
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005254 chloride channel activity ISS
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
Tight junction interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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