ENSMUSG00000047501


Mus musculus

Features
Gene ID: ENSMUSG00000047501
  
Biological name :Cldn4
  
Synonyms : Claudin-4 / Cldn4 / O35054
  
Possible biological names infered from orthology : O14493
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 134945119
Gene end: 134946934
  
Corresponding Affymetrix probe sets: 10534395 (MoGene1.0st)   1418283_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053420
NCBI entrez gene - 12740     See in Manteia.
MGI - MGI:1313314
RefSeq - NM_009903
RefSeq Peptide - NP_034033
swissprot - O35054
swissprot - Q3UM35
Ensembl - ENSMUSG00000047501
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cldnaENSDARG00000069888Danio rerio
 cldnbENSDARG00000009544Danio rerio
 cldncENSDARG00000015955Danio rerio
 cldndENSDARG00000006580Danio rerio
 cldneENSDARG00000043128Danio rerio
 cldnfENSDARG00000043133Danio rerio
 cldngENSDARG00000003701Danio rerio
 cldnhENSDARG00000069503Danio rerio
 zgc:112437ENSDARG00000009215Danio rerio
 zgc:136892ENSDARG00000069505Danio rerio
 CLDN4ENSG00000189143Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cldn3 / Q9Z0G9 / Claudin-3 / O15551*ENSMUSG0000007047369
Cldn6 / Q9Z262 / Claudin-6 / P56747*ENSMUSG0000002390661
Cldn9 / Q9Z0S7 / Claudin-9 / O95484*ENSMUSG0000006672061
Cldn5 / O54942 / Claudin-5 / O00501*ENSMUSG0000004137850
Cldn7 / Q9Z261 / Claudin-7 / O95471*ENSMUSG0000001856950
Cldn14 / Q9Z0S3 / Claudin-14 / O95500*ENSMUSG0000004710946
Cldn19 / Q9ET38 / Claudin-19 / Q8N6F1*ENSMUSG0000006605846
Cldn1 / O88551 / Claudin-1 / O95832*ENSMUSG0000002251245
Cldn8 / Q9Z260 / Claudin-8 / P56748*ENSMUSG0000005052044
Cldn2 / O88552 / Claudin-2 / P57739*ENSMUSG0000004723039


Protein motifs (from Interpro)
Interpro ID Name
 IPR003550  Claudin-4
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0061436 establishment of skin barrier IEA
 biological_processGO:0070293 renal absorption IMP
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction ISO
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane IDA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005254 chloride channel activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0000516 abnormal urinary system morphology "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0000535 luminal epithelium of ureter hyperplasia "increased cell number in the lumenal epithelium of the tube that conducts the urine from the renal pelvis to the bladder" [J:56641]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rspo3tm1.1Arte/Rspo3tm1.1Arte
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1)

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003016 increased circulating bicarbonate level "elevated concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003028 alkalosis "a pathological condition characterized by a decrease in the hydrogen ion concentration of arterial blood; caused by an increase in the concentration of alkaline compounds, or by a decrease in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003589 abnormal ureter physiology "anomalous function of the tube that conducts the urine from the renal pelvis to the bladder" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhrs3tm1(NCOM)Mfgc/Dhrs3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010107 abnormal renal reabsorption "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Cldn4tm1.1Jhou/Cldn4tm1.1Jhou,Tg(Aqp2-cre)1Dek/0
Genetic Background: B6.Cg-Cldn4tm1.1Jhou Tg(Aqp2-cre)1Dek

 MP:0010109 abnormal renal sodium reabsorption "any anomaly in the process by which sodium ions are transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cldn4tm1.1Jhou/Cldn4tm1.1Jhou,Tg(Aqp2-cre)1Dek/0
Genetic Background: B6.Cg-Cldn4tm1.1Jhou Tg(Aqp2-cre)1Dek

 MP:0010111 abnormal renal calcium reabsorption "any anomaly in the process by which calcium ions are transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0011336 abnormal kidney pelvis urothelium morphology "any structural anomaly of the epithelial lining of the luminal space of the kidney pelvis" [MGI:csmith]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0011459 increased urine chloride ion level "abnormally large amounts of chloride ion in the urine" [MGI:csmith]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Cldn4tm1.1Jhou/Cldn4tm1.1Jhou,Tg(Aqp2-cre)1Dek/0
Genetic Background: B6.Cg-Cldn4tm1.1Jhou Tg(Aqp2-cre)1Dek

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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