ENSMUSG00000050520


Mus musculus

Features
Gene ID: ENSMUSG00000050520
  
Biological name :Cldn8
  
Synonyms : Claudin-8 / Cldn8 / Q9Z260
  
Possible biological names infered from orthology : P56748
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C3.3
Gene start: 88560828
Gene end: 88563183
  
Corresponding Affymetrix probe sets: 10440647 (MoGene1.0st)   1449091_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051887
NCBI entrez gene - 54420     See in Manteia.
MGI - MGI:1859286
RefSeq - NM_018778
RefSeq Peptide - NP_061248
swissprot - Q3UZK2
swissprot - Q9Z260
Ensembl - ENSMUSG00000050520
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cldn17ENSDARG00000099950Danio rerio
 zgc:110333ENSDARG00000040628Danio rerio
 ENSGALG00000015841Gallus gallus
 ENSGALG00000044073Gallus gallus
 CLDN8ENSG00000156284Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cldn9 / Q9Z0S7 / Claudin-9 / O95484*ENSMUSG0000006672045
Cldn6 / Q9Z262 / Claudin-6 / P56747*ENSMUSG0000002390643
Cldn3 / Q9Z0G9 / Claudin-3 / O15551*ENSMUSG0000007047342
Cldn4 / O35054 / Claudin-4 / O14493*ENSMUSG0000004750141
Cldn5 / O54942 / Claudin-5 / O00501*ENSMUSG0000004137840
Cldn7 / Q9Z261 / Claudin-7 / O95471*ENSMUSG0000001856939
Cldn1 / O88551 / Claudin-1 / O95832*ENSMUSG0000002251235
Cldn14 / Q9Z0S3 / Claudin-14 / O95500*ENSMUSG0000004710935
Cldn19 / Q9ET38 / Claudin-19 / Q8N6F1*ENSMUSG0000006605834
Cldn2 / O88552 / Claudin-2 / P57739*ENSMUSG0000004723033


Protein motifs (from Interpro)
Interpro ID Name
 IPR003926  Claudin-8
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016327 apicolateral plasma membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

 MP:0003016 increased circulating bicarbonate level "elevated concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

 MP:0003028 alkalosis "a pathological condition characterized by a decrease in the hydrogen ion concentration of arterial blood; caused by an increase in the concentration of alkaline compounds, or by a decrease in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

 MP:0004119 hypokalemia "excessively low concentrations of potassium in the circulating blood; may be chronic or due to gastrointestinal and kidney depletion due to infection" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

 MP:0011459 increased urine chloride ion level "abnormally large amounts of chloride ion in the urine" [MGI:csmith]
Show

Allelic Composition: Mbpshi/Mbpshi,Pmp2tm1.1(KOMP)Vlcg/Pmp2tm1.1(KOMP)Vlcg
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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