ENSMUSG00000024109


Mus musculus

Features
Gene ID: ENSMUSG00000024109
  
Biological name :Nrxn1
  
Synonyms : Neurexin-1 / Nrxn1 / P0DI97 / Q9CS84
  
Possible biological names infered from orthology : P58400 / Q9ULB1
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E5
Gene start: 90033631
Gene end: 91093071
  
Corresponding Affymetrix probe sets: 10453518 (MoGene1.0st)   1428240_at (Mouse Genome 430 2.0 Array)   1433413_at (Mouse Genome 430 2.0 Array)   1439358_a_at (Mouse Genome 430 2.0 Array)   1439359_x_at (Mouse Genome 430 2.0 Array)   1442501_at (Mouse Genome 430 2.0 Array)   1447216_at (Mouse Genome 430 2.0 Array)   1454691_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135241
Ensembl peptide - ENSMUSP00000134402
Ensembl peptide - ENSMUSP00000135301
Ensembl peptide - ENSMUSP00000146701
Ensembl peptide - ENSMUSP00000142891
Ensembl peptide - ENSMUSP00000142815
Ensembl peptide - ENSMUSP00000142650
Ensembl peptide - ENSMUSP00000142621
Ensembl peptide - ENSMUSP00000057294
Ensembl peptide - ENSMUSP00000072458
Ensembl peptide - ENSMUSP00000124116
Ensembl peptide - ENSMUSP00000124561
Ensembl peptide - ENSMUSP00000125407
Ensembl peptide - ENSMUSP00000125561
Ensembl peptide - ENSMUSP00000133389
Ensembl peptide - ENSMUSP00000133491
Ensembl peptide - ENSMUSP00000133724
NCBI entrez gene - 18189     See in Manteia.
MGI - MGI:1096391
RefSeq - XM_017317317
RefSeq - XM_017317296
RefSeq - XM_017317297
RefSeq - XM_017317298
RefSeq - XM_017317299
RefSeq - XM_017317300
RefSeq - XM_017317301
RefSeq - XM_017317302
RefSeq - XM_017317303
RefSeq - XM_017317304
RefSeq - XM_017317306
RefSeq - XM_017317307
RefSeq - XM_017317308
RefSeq - XM_017317309
RefSeq - XM_017317310
RefSeq - XM_017317311
RefSeq - XM_017317312
RefSeq - XM_017317314
RefSeq - XM_017317315
RefSeq - XM_017317316
RefSeq - NM_020252
RefSeq - NM_177284
RefSeq - XM_006523811
RefSeq - XM_006523812
RefSeq - XM_006523815
RefSeq - XM_006523816
RefSeq - XM_006523818
RefSeq - XM_011246318
RefSeq - XM_017317294
RefSeq - XM_017317295
RefSeq Peptide - NP_001333888
RefSeq Peptide - NP_001333889
RefSeq Peptide - NP_001333891
RefSeq Peptide - NP_001334348
RefSeq Peptide - NP_064648
RefSeq Peptide - NP_796258
RefSeq Peptide - NP_001333887
swissprot - H3BK93
swissprot - A0A0G2JE65
swissprot - Q9CS84
swissprot - A0A0G2JE40
swissprot - E0CZA5
swissprot - P0DI97
swissprot - E0CY11
swissprot - A0A140LI71
swissprot - A0A0H2UH29
swissprot - A0A0G2JES8
swissprot - G3UWQ9
swissprot - H3BK41
Ensembl - ENSMUSG00000024109
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NRXN1ENSGALG00000009107Gallus gallus
 NRXN1ENSG00000179915Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nrxn2 / neurexin II / P58401* / Q9P2S2* / neurexin 2*ENSMUSG0000003376869
Nrxn3 / Q6P9K9 / Q8C985 / Neurexin-3 / Q9Y4C0* / Q9HDB5*ENSMUSG0000006639269
Q99P47 / Cntnap4 / Contactin-associated protein-like 4 / Q9C0A0*ENSMUSG0000003177220
Q9CPW0 / Cntnap2 / Contactin-associated protein-like 2 / Q9UHC6*ENSMUSG0000003941919
Q0V8T7 / Cntnap5c / Contactin-associated protein like 5-3 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000003804819
Q0V8T9 / Cntnap5a / Contactin-associated protein like 5-1 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000007069519
Cntnap3 / contactin associated protein-like 3 / Q96NU0* / Q9BZ76* / CNTNAP3B* / BX088645.1* / contactin associated protein like 3B*ENSMUSG0000003306318
Q0V8T8 / Cntnap5b / Contactin-associated protein like 5-2 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000006702818
O54991 / Cntnap1 / Contactin-associated protein 1 / P78357*ENSMUSG0000001716718


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027789  Syndecan/Neurexin domain
 IPR037440  Neurexin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006904 vesicle docking involved in exocytosis ISO
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IGI
 biological_processGO:0007158 neuron cell-cell adhesion IDA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007268 chemical synaptic transmission IGI
 biological_processGO:0007269 neurotransmitter secretion TAS
 biological_processGO:0007416 synapse assembly IGI
 biological_processGO:0007612 learning IMP
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010739 positive regulation of protein kinase A signaling ISO
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0021707 cerebellar granule cell differentiation IGI
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0031175 neuron projection development ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0035176 social behavior ISO
 biological_processGO:0035418 protein localization to synapse IDA
 biological_processGO:0042297 vocal learning ISO
 biological_processGO:0042551 neuron maturation IDA
 biological_processGO:0045184 establishment of protein localization IDA
 biological_processGO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway ISO
 biological_processGO:0046847 filopodium assembly IMP
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0051490 negative regulation of filopodium assembly IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISO
 biological_processGO:0051965 positive regulation of synapse assembly IGI
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0060134 prepulse inhibition IMP
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0071625 vocalization behavior ISO
 biological_processGO:0090126 protein-containing complex assembly involved in synapse maturation IDA
 biological_processGO:0090129 positive regulation of synapse maturation IDA
 biological_processGO:0097091 synaptic vesicle clustering IDA
 biological_processGO:0097104 postsynaptic membrane assembly IDA
 biological_processGO:0097105 presynaptic membrane assembly IDA
 biological_processGO:0097112 gamma-aminobutyric acid receptor clustering IDA
 biological_processGO:0097114 NMDA glutamate receptor clustering IDA
 biological_processGO:0097116 gephyrin clustering involved in postsynaptic density assembly IDA
 biological_processGO:0097117 guanylate kinase-associated protein clustering IDA
 biological_processGO:0097118 neuroligin clustering involved in postsynaptic membrane assembly IDA
 biological_processGO:0097119 postsynaptic density protein 95 clustering IDA
 biological_processGO:0097120 receptor localization to synapse IDA
 biological_processGO:0099560 synaptic membrane adhesion IMP
 biological_processGO:1900020 positive regulation of protein kinase C activity ISO
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IDA
 biological_processGO:2000310 regulation of NMDA receptor activity IDA
 biological_processGO:2000311 regulation of AMPA receptor activity IDA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IMP
 biological_processGO:2000821 regulation of grooming behavior IMP
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030139 endocytic vesicle ISS
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0042734 presynaptic membrane IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0044295 axonal growth cone IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0060076 excitatory synapse IC
 cellular_componentGO:0060077 inhibitory synapse IC
 molecular_functionGO:0004888 transmembrane signaling receptor activity IDA
 molecular_functionGO:0005105 type 1 fibroblast growth factor receptor binding ISO
 molecular_functionGO:0005246 calcium channel regulator activity IGI
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0033130 acetylcholine receptor binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IDA
 molecular_functionGO:0050839 cell adhesion molecule binding IPI
 molecular_functionGO:0097109 neuroligin family protein binding IPI


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0001902 reduced NMDA -mediated synaptic currents "reduction in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zbtb7bhpls/Zbtb7bhpls
Genetic Background: involves: C57BL/6JAnu

Allelic Composition: Nrxn1tm2Sud/Nrxn1tm2Sud,Nrxn2tm2Sud/Nrxn2tm2Sud,Nrxn3tm2Sud/Nrxn3tm2Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nrxn1tm3Sud/Nrxn1tm3Sud
Genetic Background: B6.129-Nrxn1tm3Sud

Allelic Composition: Nrxn1tm5Sud/Nrxn1tm5Sud
Genetic Background: involves: C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0002915 abnormal synaptic depression "changes in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

Allelic Composition: Adgrl1tm1Sud/Adgrl1tm1Sud,Nrxn1tm1Sud/Nrxn1tm1Sud
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0003795 abnormal bone structure 
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0004494 abnormal synaptic glutamate release "aberrant secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adgrl1tm1Sud/Adgrl1tm1Sud,Nrxn1tm1Sud/Nrxn1tm1Sud
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0004495 decreased synaptic glutamate release "reduced secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

Allelic Composition: Adgrl1tm1Sud/Adgrl1tm1Sud,Nrxn1tm1Sud/Nrxn1tm1Sud
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0004807 abnormal paired pulse inhibition "defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0005574 decreased breathing frequency "fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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