ENSMUSG00000039419


Mus musculus

Features
Gene ID: ENSMUSG00000039419
  
Biological name :Cntnap2
  
Synonyms : Cntnap2 / Contactin-associated protein-like 2 / Q9CPW0
  
Possible biological names infered from orthology : Q9UHC6
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B2.2
Gene start: 45059357
Gene end: 47304213
  
Corresponding Affymetrix probe sets: 10537851 (MoGene1.0st)   1422798_at (Mouse Genome 430 2.0 Array)   1437782_at (Mouse Genome 430 2.0 Array)   1439750_at (Mouse Genome 430 2.0 Array)   1450758_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110288
Ensembl peptide - ENSMUSP00000147145
Ensembl peptide - ENSMUSP00000143528
Ensembl peptide - ENSMUSP00000142656
Ensembl peptide - ENSMUSP00000056299
NCBI entrez gene - 66797     See in Manteia.
MGI - MGI:1914047
RefSeq - NM_025771
RefSeq - NM_001004357
RefSeq Peptide - NP_001004357
RefSeq Peptide - NP_080047
swissprot - Q9CPW0
swissprot - A0A140LJB1
swissprot - A0A0G2JE70
swissprot - Q3SYI6
swissprot - E9QNF7
Ensembl - ENSMUSG00000039419
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cntnap2aENSDARG00000058969Danio rerio
 cntnap2bENSDARG00000074558Danio rerio
 CNTNAP2ENSGALG00000031971Gallus gallus
 Q9UHC6ENSG00000174469Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q0V8T9 / Cntnap5a / Contactin-associated protein like 5-1 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000007069548
Q0V8T8 / Cntnap5b / Contactin-associated protein like 5-2 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000006702847
Q99P47 / Cntnap4 / Contactin-associated protein-like 4 / Q9C0A0*ENSMUSG0000003177247
Q0V8T7 / Cntnap5c / Contactin-associated protein like 5-3 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000003804847
Cntnap3 / contactin associated protein-like 3 / Q96NU0* / Q9BZ76* / CNTNAP3B* / BX088645.1* / contactin associated protein like 3B*ENSMUSG0000003306344
O54991 / Cntnap1 / Contactin-associated protein 1 / P78357*ENSMUSG0000001716743
Nrxn2 / neurexin II / P58401* / Q9P2S2* / neurexin 2*ENSMUSG0000003376822
Nrxn3 / Q6P9K9 / Q8C985 / Neurexin-3 / Q9Y4C0* / Q9HDB5*ENSMUSG0000006639222
Nrxn1 / P0DI97 / Q9CS84 / Neurexin-1 / P58400* / Q9ULB1*ENSMUSG0000002410921


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR008979  Galactose-binding-like domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR029831  Contactin-associated protein-like 2
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007612 learning ISO
 biological_processGO:0008038 neuron recognition TAS
 biological_processGO:0021756 striatum development IEA
 biological_processGO:0021761 limbic system development IEP
 biological_processGO:0021794 thalamus development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030534 adult behavior ISO
 biological_processGO:0031175 neuron projection development IGI
 biological_processGO:0035176 social behavior ISO
 biological_processGO:0042297 vocal learning ISO
 biological_processGO:0045163 clustering of voltage-gated potassium channels IMP
 biological_processGO:0048812 neuron projection morphogenesis IMP
 biological_processGO:0071109 superior temporal gyrus development IEA
 biological_processGO:0071205 protein localization to juxtaparanode region of axon IMP
 biological_processGO:0071625 vocalization behavior ISO
 cellular_componentGO:0005769 early endosome ISS
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISO
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030673 axolemma ISS
 cellular_componentGO:0033010 paranodal junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044224 juxtaparanode region of axon IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: Not Specified

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

Allelic Composition: Cntnap2tm2Pele/Cntnap2tm2Pele
Genetic Background: B6.129(Cg)-Cntnap2tm2Pele

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0001984 abnormal olfaction "change in the ability to smell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0003462 abnormal response to novel odor "altered investigative behavior from controls in reactions associated with exposing an animal to a novel odor" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Cntnap2tm2Pele/Cntnap2tm2Pele
Genetic Background: B6.129(Cg)-Cntnap2tm2Pele

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0014115 cognitive inflexibility "inability to change attention or a cognitive behavior as an adaptation to the demands of external stimuli" [PMID:26112128]
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Allelic Composition: Cntnap2tm2Pele/Cntnap2tm2Pele
Genetic Background: B6.129(Cg)-Cntnap2tm2Pele

 MP:0020340 abnormal inhibitory learning "anomaly in the process by which a subject learns to suppress a prior learned response" [http://cognitivedefusion.tumblr.com/post/90402024947/what-is-inhibitory-learning, ORCID: orcid.org/0000-0003-4606-0597, PMID:19321764]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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