ENSMUSG00000066392


Mus musculus

Features
Gene ID: ENSMUSG00000066392
  
Biological name :Nrxn3
  
Synonyms : Neurexin-3 / Nrxn3 / Q6P9K9 / Q8C985
  
Possible biological names infered from orthology : Q9HDB5 / Q9Y4C0
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: D3
Gene start: 88722876
Gene end: 90334935
  
Corresponding Affymetrix probe sets: 10397575 (MoGene1.0st)   1432931_at (Mouse Genome 430 2.0 Array)   1433788_at (Mouse Genome 430 2.0 Array)   1438193_at (Mouse Genome 430 2.0 Array)   1439629_at (Mouse Genome 430 2.0 Array)   1456137_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127926
Ensembl peptide - ENSMUSP00000127407
Ensembl peptide - ENSMUSP00000129678
Ensembl peptide - ENSMUSP00000139879
Ensembl peptide - ENSMUSP00000050075
Ensembl peptide - ENSMUSP00000105757
Ensembl peptide - ENSMUSP00000105760
NCBI entrez gene - 18191     See in Manteia.
MGI - MGI:1096389
RefSeq - XM_017314989
RefSeq - XM_011244011
RefSeq - XM_017314982
RefSeq - XM_017314983
RefSeq - XM_017314984
RefSeq - XM_017314985
RefSeq - XM_017314986
RefSeq - XM_017314987
RefSeq - XM_017314988
RefSeq - NM_001198587
RefSeq - NM_001252074
RefSeq - NM_172544
RefSeq - XM_006515534
RefSeq - XM_006515535
RefSeq - XM_006515536
RefSeq - XM_006515537
RefSeq - XM_006515538
RefSeq - XM_006515539
RefSeq - XM_006515540
RefSeq - XM_006515541
RefSeq - XM_006515542
RefSeq - XM_006515543
RefSeq - XM_006515544
RefSeq - XM_006515545
RefSeq - XM_006515546
RefSeq - XM_006515547
RefSeq - XM_006515548
RefSeq - XM_006515549
RefSeq - XM_006515550
RefSeq - XM_006515551
RefSeq - XM_006515552
RefSeq - XM_006515553
RefSeq - XM_006515554
RefSeq - XM_006515555
RefSeq - XM_006515556
RefSeq - XM_006515557
RefSeq - XM_006515558
RefSeq - XM_006515559
RefSeq - XM_006515560
RefSeq - XM_006515567
RefSeq - XM_006515568
RefSeq - XM_006515569
RefSeq - XM_006515570
RefSeq Peptide - NP_001185516
RefSeq Peptide - NP_001239003
RefSeq Peptide - NP_766132
swissprot - Q8C985
swissprot - E9Q3Q4
swissprot - A0A087WPQ9
swissprot - E9Q2X2
swissprot - Q6P9K9
Ensembl - ENSMUSG00000066392
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrxn3aENSDARG00000043746Danio rerio
 nrxn3bENSDARG00000062693Danio rerio
 NRXN3ENSGALG00000010518Gallus gallus
 NRXN3ENSG00000021645Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nrxn1 / P0DI97 / Q9CS84 / Neurexin-1 / P58400* / Q9ULB1*ENSMUSG0000002410966
Nrxn2 / neurexin II / P58401* / Q9P2S2* / neurexin 2*ENSMUSG0000003376866
Q9CPW0 / Cntnap2 / Contactin-associated protein-like 2 / Q9UHC6*ENSMUSG0000003941919
Q99P47 / Cntnap4 / Contactin-associated protein-like 4 / Q9C0A0*ENSMUSG0000003177219
O54991 / Cntnap1 / Contactin-associated protein 1 / P78357*ENSMUSG0000001716718
Cntnap3 / contactin associated protein-like 3 / Q96NU0* / Q9BZ76* / CNTNAP3B* / BX088645.1* / contactin associated protein like 3B*ENSMUSG0000003306318
Q0V8T9 / Cntnap5a / Contactin-associated protein like 5-1 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000007069518
Q0V8T7 / Cntnap5c / Contactin-associated protein like 5-3 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000003804818
Q0V8T8 / Cntnap5b / Contactin-associated protein like 5-2 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000006702818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR027789  Syndecan/Neurexin domain
 IPR037440  Neurexin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007268 chemical synaptic transmission IGI
 biological_processGO:0007269 neurotransmitter secretion IGI
 biological_processGO:0007416 synapse assembly IGI
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042734 presynaptic membrane ISA
 molecular_functionGO:0005246 calcium channel regulator activity IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Flgft/Flgft
Genetic Background: STOCK a/a Tmem79ma Flgft/J

 MP:0001902 reduced NMDA -mediated synaptic currents "reduction in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb7bhpls/Zbtb7bhpls
Genetic Background: involves: C57BL/6JAnu

Allelic Composition: Nrxn1tm2Sud/Nrxn1tm2Sud,Nrxn2tm2Sud/Nrxn2tm2Sud,Nrxn3tm2Sud/Nrxn3tm2Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0002915 abnormal synaptic depression "changes in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Flgft/Flgft
Genetic Background: STOCK a/a Tmem79ma Flgft/J

 MP:0004807 abnormal paired pulse inhibition "defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Flgft/Flgft
Genetic Background: STOCK a/a Tmem79ma Flgft/J

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nrxn2tm1Sud/Nrxn2tm1Sud,Nrxn3tm1Sud/Nrxn3tm1Sud
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nrxn3tm1Sud/Nrxn3tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0020551 abnormal postsynaptic density morphology "any structural anomaly of the electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymetric, neuron-neuron synapse" [GO:0014069]
Show

Allelic Composition: Flgft/Flgft
Genetic Background: STOCK a/a Tmem79ma Flgft/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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