ENSMUSG00000033768


Mus musculus

Features
Gene ID: ENSMUSG00000033768
  
Biological name :Nrxn2
  
Synonyms : neurexin II / Nrxn2
  
Possible biological names infered from orthology : neurexin 2 / P58401 / Q9P2S2
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 6418731
Gene end: 6544169
  
Corresponding Affymetrix probe sets: 10460987 (MoGene1.0st)   1435907_at (Mouse Genome 430 2.0 Array)   1455499_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109085
Ensembl peptide - ENSMUSP00000122920
Ensembl peptide - ENSMUSP00000119762
Ensembl peptide - ENSMUSP00000118878
Ensembl peptide - ENSMUSP00000109089
Ensembl peptide - ENSMUSP00000109088
Ensembl peptide - ENSMUSP00000109086
Ensembl peptide - ENSMUSP00000076424
NCBI entrez gene - 18190     See in Manteia.
MGI - MGI:1096362
RefSeq - NM_001205234
RefSeq - NM_001205235
RefSeq - NM_020253
RefSeq Peptide - NP_001192163
RefSeq Peptide - NP_001192164
RefSeq Peptide - NP_064649
swissprot - E9Q7X7
swissprot - F6Y027
swissprot - E9Q5N7
swissprot - E9PUN2
swissprot - E9PUN1
swissprot - E9PUN0
swissprot - E9PUM9
swissprot - F6WN33
Ensembl - ENSMUSG00000033768
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 neurexin 2ENSDARG00000113112Danio rerio
 nrxn2bENSDARG00000063150Danio rerio
 NRXN2ENSG00000110076Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nrxn1 / P0DI97 / Q9CS84 / Neurexin-1 / P58400* / Q9ULB1*ENSMUSG0000002410961
Nrxn3 / Q6P9K9 / Q8C985 / Neurexin-3 / Q9Y4C0* / Q9HDB5*ENSMUSG0000006639261
Q99P47 / Cntnap4 / Contactin-associated protein-like 4 / Q9C0A0*ENSMUSG0000003177219
O54991 / Cntnap1 / Contactin-associated protein 1 / P78357*ENSMUSG0000001716717
Q9CPW0 / Cntnap2 / Contactin-associated protein-like 2 / Q9UHC6*ENSMUSG0000003941917
Q0V8T8 / Cntnap5b / Contactin-associated protein like 5-2 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000006702817
Q0V8T9 / Cntnap5a / Contactin-associated protein like 5-1 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000007069517
Cntnap3 / contactin associated protein-like 3 / Q96NU0* / Q9BZ76* / CNTNAP3B* / BX088645.1* / contactin associated protein like 3B*ENSMUSG0000003306317
Q0V8T7 / Cntnap5c / Contactin-associated protein like 5-3 / Q8WYK1* / CNTNAP5* / contactin associated protein like 5*ENSMUSG0000003804817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR027789  Syndecan/Neurexin domain
 IPR037440  Neurexin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007268 chemical synaptic transmission IGI
 biological_processGO:0007269 neurotransmitter secretion IGI
 biological_processGO:0007416 synapse assembly IGI
 biological_processGO:0030534 adult behavior ISO
 biological_processGO:0035176 social behavior ISO
 biological_processGO:0042297 vocal learning ISO
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071625 vocalization behavior ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042734 presynaptic membrane ISA
 molecular_functionGO:0005246 calcium channel regulator activity IGI
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gata1tm5(GATA3)Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grid2ho/Grid2ho
Genetic Background: involves: C57BLKS/J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Grid2ho/Grid2ho
Genetic Background: involves: C57BLKS/J

 MP:0001902 reduced NMDA -mediated synaptic currents "reduction in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata1tm5(GATA3)Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb7bhpls/Zbtb7bhpls
Genetic Background: involves: C57BL/6JAnu

Allelic Composition: Nrxn1tm2Sud/Nrxn1tm2Sud,Nrxn2tm2Sud/Nrxn2tm2Sud,Nrxn3tm2Sud/Nrxn3tm2Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nrxn2tm4Sud/Nrxn2tm4Sud
Genetic Background: involves: C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Grid2ho/Grid2ho
Genetic Background: involves: C57BLKS/J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nrxn2tm1Sud/Nrxn2tm1Sud,Nrxn3tm1Sud/Nrxn3tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0002915 abnormal synaptic depression "changes in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gata1tm5(GATA3)Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Grid2ho/Grid2ho
Genetic Background: involves: C57BLKS/J

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0004807 abnormal paired pulse inhibition "defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud,Nrxn2tm1Sud/Nrxn2tm1Sud
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nrxn2tm1Sud/Nrxn2tm1Sud,Nrxn3tm1Sud/Nrxn3tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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