ENSMUSG00000024131


Mus musculus

Features
Gene ID: ENSMUSG00000024131
  
Biological name :Slc3a1
  
Synonyms : Neutral and basic amino acid transport protein rBAT / Q91WV7 / Slc3a1
  
Possible biological names infered from orthology : Q07837 / solute carrier family 3 member 1
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E4
Gene start: 85028347
Gene end: 85064243
  
Corresponding Affymetrix probe sets: 10447264 (MoGene1.0st)   1448741_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024944
NCBI entrez gene - 20532     See in Manteia.
MGI - MGI:1195264
RefSeq - NM_009205
RefSeq Peptide - NP_033231
swissprot - Q91WV7
Ensembl - ENSMUSG00000024131
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc3a1ENSDARG00000017165Danio rerio
 SLC3A1ENSGALG00000009973Gallus gallus
 Q07837ENSG00000138079Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P10852 / Slc3a2 / solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 / P08195* / solute carrier family 3 member 2*ENSMUSG0000001009519


Protein motifs (from Interpro)
Interpro ID Name
 IPR006047  Glycosyl hydrolase, family 13, catalytic domain
 IPR017853  Glycoside hydrolase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006865 amino acid transport IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005774 vacuolar membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Amino acid transport across the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1m1Crl/Slc3a1m1Crl
Genetic Background: 129S2/SvPasCrl

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

Allelic Composition: Slc3a1m1Crl/Slc3a1m1Crl
Genetic Background: 129S2/SvPasCrl

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc3a1m1Crl/Slc3a1m1Crl
Genetic Background: 129S2/SvPasCrl

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

Allelic Composition: Slc3a1m1Crl/Slc3a1m1Crl
Genetic Background: 129S2/SvPasCrl

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1m1Crl/Slc3a1m1Crl
Genetic Background: 129S2/SvPasCrl

 MP:0003587 ureter obstruction "any impediment, blockage, or reversal of the normal flow of the urine towards the bladder" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Slc3a1m1Crl/Slc3a1m1Crl
Genetic Background: 129S2/SvPasCrl

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0005360 urolithiasis "presence of calculi in any part of the urinary system" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85461, J:85462]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1m1Crl/Slc3a1m1Crl
Genetic Background: 129S2/SvPasCrl

 MP:0009552 urinary bladder obstruction "any impediment or blockage of the musculomembranous elastic bag serving as a storage place for urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc3a1m1Crl/Slc3a1m1Crl
Genetic Background: 129S2/SvPasCrl

 MP:0009644 uremia "an excess of urea, creatinine, and other nitrogenous end products of protein and amino acid metabolism in the blood; usually indicative of kidney dysfunction" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0009645 crystalluria "excretion of crystalline material in the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0011422 kidney medulla atrophy "acquired diminution of the size of the inner portion of the kidney consisting of the renal pyramids, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0011423 kidney cortex atrophy "acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0011468 abnormal urine amino acid level "any anomaly in the amount in the urine of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group" [CHEBI:33709, MGI:csmith]
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Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0011625 cystolithiasis "caliculi, or a solid concretion or crystal aggregation, found in the urinary bladder; often embedded in a glycoprotein matrix which may also contain some nonglycoproteins when associated with infection" [MGI:csmith]
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Allelic Composition: Slc3a1m1Crl/Slc3a1m1Crl
Genetic Background: 129S2/SvPasCrl

 MP:0020400 cystinuria "excretion of excessive amounts of cystine in the urine" [HP:0003131]
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Allelic Composition: Slc3a1m1Crl/Slc3a1m1Crl
Genetic Background: 129S2/SvPasCrl

 MP:0020401 argininuria "excretion of excessive amounts of arginine in the urine" [HP:0003268]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1m1Crl/Slc3a1m1Crl
Genetic Background: 129S2/SvPasCrl

 MP:0020402 ornithinuria "excretion of excessive amounts of ornithine in the urine" [HP:0003532]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1m1Crl/Slc3a1m1Crl
Genetic Background: 129S2/SvPasCrl

 MP:0020403 lysinuria "excretion of excessive amounts of lysine in the urine" [http://medical-dictionary.thefreedictionary.com/lysinuria]
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Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Slc3a1m1Crl/Slc3a1m1Crl
Genetic Background: 129S2/SvPasCrl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030492 Q9QXA6 / Slc7a9 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 / P82251* / solute carrier family 7 member 9*  / complex






 

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