ENSMUSG00000030492


Mus musculus

Features
Gene ID: ENSMUSG00000030492
  
Biological name :Slc7a9
  
Synonyms : Q9QXA6 / Slc7a9 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
  
Possible biological names infered from orthology : P82251 / solute carrier family 7 member 9
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B2
Gene start: 35448796
Gene end: 35466036
  
Corresponding Affymetrix probe sets: 10552193 (MoGene1.0st)   1448783_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032703
Ensembl peptide - ENSMUSP00000112726
Ensembl peptide - ENSMUSP00000113181
Ensembl peptide - ENSMUSP00000117352
NCBI entrez gene - 30962     See in Manteia.
MGI - MGI:1353656
RefSeq - XM_011250592
RefSeq - NM_001199015
RefSeq - NM_001199016
RefSeq - NM_021291
RefSeq - XM_006540044
RefSeq - XM_006540045
RefSeq - XM_006540046
RefSeq - XM_006540047
RefSeq - XM_011250591
RefSeq Peptide - NP_001185944
RefSeq Peptide - NP_001185945
RefSeq Peptide - NP_067266
swissprot - F7AUJ6
swissprot - Q3UQE3
swissprot - Q9QXA6
Ensembl - ENSMUSG00000030492
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc7a9ENSDARG00000005894Danio rerio
 SLC7A9ENSGALG00000021158Gallus gallus
 P82251ENSG00000021488Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc7a15 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 15ENSMUSG0000002060044
Q9Z127 / Slc7a5 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 / Q01650* / solute carrier family 7 member 5*ENSMUSG0000004001043
Q9QXW9 / Slc7a8 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 / Q9UHI5* / solute carrier family 7 member 8*ENSMUSG0000002218043
Q8BGK6 / Slc7a6 / Mus musculus solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (Slc7a6), transcript variant 4, mRNA. / Q92536* / solute carrier family 7 member 6*ENSMUSG0000003190442
P63115 / Slc7a10 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 / Q9NS82* / solute carrier family 7 member 10*ENSMUSG0000003049542
Q9Z1K8 / Slc7a7 / Y+L amino acid transporter 1 / Q9UM01* / solute carrier family 7 member 7*ENSMUSG0000000095842
Q9WTR6 / Slc7a11 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 / Q9UPY5* / solute carrier family 7 member 11*ENSMUSG0000002773741
Q91WN3 / Slc7a13 / Solute carrier family 7 member 13 / Q8TCU3*ENSMUSG0000004105232
Slc7a12 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 12ENSMUSG0000003971028


Protein motifs (from Interpro)
Interpro ID Name
 IPR002293  Amino acid/polyamine transporter I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003333 amino acid transmembrane transport IEA
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0015804 neutral amino acid transport IEA
 biological_processGO:0015811 L-cystine transport IBA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0031526 brush border membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015171 amino acid transmembrane transporter activity IEA
 molecular_functionGO:0015175 neutral amino acid transmembrane transporter activity IBA
 molecular_functionGO:0015184 L-cystine transmembrane transporter activity IBA
 molecular_functionGO:0015297 antiporter activity IBA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0042605 peptide antigen binding ISS


Pathways (from Reactome)
Pathway description
Basigin interactions
Amino acid transport across the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Slc7a9tm1Nune/Slc7a9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0005360 urolithiasis "presence of calculi in any part of the urinary system" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85461, J:85462]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0009645 crystalluria "excretion of crystalline material in the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0011799 increased urinary bladder weight "greater than average weight of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys compared to controls" [MGI:anna]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0020400 cystinuria "excretion of excessive amounts of cystine in the urine" [HP:0003131]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Slc7a9tm1Nune/Slc7a9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0020401 argininuria "excretion of excessive amounts of arginine in the urine" [HP:0003268]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Slc7a9tm1Nune/Slc7a9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0020402 ornithinuria "excretion of excessive amounts of ornithine in the urine" [HP:0003532]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Slc7a9tm1Nune/Slc7a9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0020403 lysinuria "excretion of excessive amounts of lysine in the urine" [http://medical-dictionary.thefreedictionary.com/lysinuria]
Show

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Slc7a9tm1Nune/Slc7a9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010095 P10852 / Slc3a2 / solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 / P08195* / solute carrier family 3 member 2*  / complex
 ENSMUSG00000024131 Q91WV7 / Slc3a1 / Neutral and basic amino acid transport protein rBAT / Q07837* / solute carrier family 3 member 1*  / complex






 

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