ENSMUSG00000030495


Mus musculus

Features
Gene ID: ENSMUSG00000030495
  
Biological name :Slc7a10
  
Synonyms : P63115 / Slc7a10 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
  
Possible biological names infered from orthology : Q9NS82 / solute carrier family 7 member 10
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B2
Gene start: 35186385
Gene end: 35201114
  
Corresponding Affymetrix probe sets: 10552143 (MoGene1.0st)   1421093_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129954
Ensembl peptide - ENSMUSP00000118331
Ensembl peptide - ENSMUSP00000127311
Ensembl peptide - ENSMUSP00000127577
Ensembl peptide - ENSMUSP00000001854
NCBI entrez gene - 53896     See in Manteia.
MGI - MGI:1858261
RefSeq - XM_017322367
RefSeq - NM_017394
RefSeq - XM_006540197
RefSeq - XM_017322364
RefSeq - XM_017322365
RefSeq - XM_017322366
RefSeq Peptide - NP_059090
swissprot - P63115
swissprot - E9Q248
swissprot - F6U9B9
swissprot - E9Q1V6
swissprot - D6RII2
Ensembl - ENSMUSG00000030495
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc7a10aENSDARG00000008100Danio rerio
 slc7a10bENSDARG00000051730Danio rerio
 SLC7A10ENSGALG00000004729Gallus gallus
 Q9NS82ENSG00000130876Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9QXW9 / Slc7a8 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 / Q9UHI5* / solute carrier family 7 member 8*ENSMUSG0000002218065
Q8BGK6 / Slc7a6 / Mus musculus solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (Slc7a6), transcript variant 4, mRNA. / Q92536* / solute carrier family 7 member 6*ENSMUSG0000003190443
Q9Z127 / Slc7a5 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 / Q01650* / solute carrier family 7 member 5*ENSMUSG0000004001043
Q9Z1K8 / Slc7a7 / Y+L amino acid transporter 1 / Q9UM01* / solute carrier family 7 member 7*ENSMUSG0000000095841
Q9WTR6 / Slc7a11 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 / Q9UPY5* / solute carrier family 7 member 11*ENSMUSG0000002773740
Q9QXA6 / Slc7a9 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 / P82251* / solute carrier family 7 member 9*ENSMUSG0000003049238
Slc7a15 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 15ENSMUSG0000002060035
Q91WN3 / Slc7a13 / Solute carrier family 7 member 13 / Q8TCU3*ENSMUSG0000004105227
Slc7a12 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 12ENSMUSG0000003971020


Protein motifs (from Interpro)
Interpro ID Name
 IPR002293  Amino acid/polyamine transporter I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0015804 neutral amino acid transport IEA
 biological_processGO:0015825 L-serine transport IBA
 biological_processGO:0042941 D-alanine transport IMP
 biological_processGO:0042942 D-serine transport IMP
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015175 neutral amino acid transmembrane transporter activity IEA
 molecular_functionGO:0015194 L-serine transmembrane transporter activity IBA
 molecular_functionGO:0015297 antiporter activity IBA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Basigin interactions
Amino acid transport across the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129P2/OlaHsd * A

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010095 P10852 / Slc3a2 / solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 / P08195* / solute carrier family 3 member 2*  / complex






 

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