ENSMUSG00000040010


Mus musculus

Features
Gene ID: ENSMUSG00000040010
  
Biological name :Slc7a5
  
Synonyms : Q9Z127 / Slc7a5 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
  
Possible biological names infered from orthology : Q01650 / solute carrier family 7 member 5
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 121881150
Gene end: 121907694
  
Corresponding Affymetrix probe sets: 10582275 (MoGene1.0st)   1418326_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041557
NCBI entrez gene - 20539     See in Manteia.
MGI - MGI:1298205
RefSeq - NM_011404
RefSeq Peptide - NP_035534
swissprot - Q9Z127
Ensembl - ENSMUSG00000040010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc7a5ENSDARG00000099265Danio rerio
 SLC7A5ENSGALG00000005845Gallus gallus
 Q01650ENSG00000103257Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9QXW9 / Slc7a8 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 / Q9UHI5* / solute carrier family 7 member 8*ENSMUSG0000002218050
Q8BGK6 / Slc7a6 / Mus musculus solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (Slc7a6), transcript variant 4, mRNA. / Q92536* / solute carrier family 7 member 6*ENSMUSG0000003190449
Q9Z1K8 / Slc7a7 / Y+L amino acid transporter 1 / Q9UM01* / solute carrier family 7 member 7*ENSMUSG0000000095846
P63115 / Slc7a10 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 / Q9NS82* / solute carrier family 7 member 10*ENSMUSG0000003049544
Q9WTR6 / Slc7a11 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 / Q9UPY5* / solute carrier family 7 member 11*ENSMUSG0000002773743
Q9QXA6 / Slc7a9 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 / P82251* / solute carrier family 7 member 9*ENSMUSG0000003049241
Slc7a15 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 15ENSMUSG0000002060035
Q91WN3 / Slc7a13 / Solute carrier family 7 member 13 / Q8TCU3*ENSMUSG0000004105227
Slc7a12 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 12ENSMUSG0000003971025


Protein motifs (from Interpro)
Interpro ID Name
 IPR002293  Amino acid/polyamine transporter I
 IPR004760  L-type amino acid transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0015804 neutral amino acid transport IBA
 biological_processGO:0015807 L-amino acid transport IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902475 L-alpha-amino acid transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0015175 neutral amino acid transmembrane transporter activity IBA
 molecular_functionGO:0015179 L-amino acid transmembrane transporter activity IDA
 molecular_functionGO:0015297 antiporter activity IBA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Basigin interactions
Amino acid transport across the plasma membrane
Tryptophan catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc7a5tm1.1Daca/Slc7a5tm1.1Daca,Tg(Tek-cre)12Flv/0
Genetic Background: B6J.Cg-Slc7a5tm1.1Daca Tg(Tek-cre)12Flv

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc7a5tm1.1Daca/Slc7a5tm1.1Daca,Tg(Tek-cre)12Flv/0
Genetic Background: B6J.Cg-Slc7a5tm1.1Daca Tg(Tek-cre)12Flv

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc7a5tm1.1Daca/Slc7a5tm1.1Daca,Tg(Tek-cre)12Flv/0
Genetic Background: B6J.Cg-Slc7a5tm1.1Daca Tg(Tek-cre)12Flv

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dvl3b2b2866Clo/Dvl3b2b2866Clo
Genetic Background: C57BL/6J-Dvl3b2b2866Clo

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dvl3b2b2866Clo/Dvl3b2b2866Clo
Genetic Background: C57BL/6J-Dvl3b2b2866Clo

Allelic Composition: Slc7a5tm1.1Daca/Slc7a5tm1.1Daca,Tg(Tek-cre)12Flv/0
Genetic Background: B6J.Cg-Slc7a5tm1.1Daca Tg(Tek-cre)12Flv

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: Slc7a5tm1.1Daca/Slc7a5tm1.1Daca,Tg(Tek-cre)12Flv/0
Genetic Background: B6J.Cg-Slc7a5tm1.1Daca Tg(Tek-cre)12Flv

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl3b2b2866Clo/Dvl3b2b2866Clo
Genetic Background: C57BL/6J-Dvl3b2b2866Clo

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc7a5tm1.1Daca/Slc7a5tm1.1Daca,Tg(Tek-cre)12Flv/0
Genetic Background: B6J.Cg-Slc7a5tm1.1Daca Tg(Tek-cre)12Flv

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Dvl3b2b2866Clo/Dvl3b2b2866Clo
Genetic Background: C57BL/6J-Dvl3b2b2866Clo

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Mecp2tm1.1Irsf/Y
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0013140 excessive vocalization "producing sound from the vocal organs more frequently or more loudly than expected" [MGI:Ahmad_Retha]
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Allelic Composition: Slc7a5tm1.1Daca/Slc7a5tm1.1Daca,Tg(Tek-cre)12Flv/0
Genetic Background: B6J.Cg-Slc7a5tm1.1Daca Tg(Tek-cre)12Flv

 MP:0013242 abnormal amino acid metabolism "any anomaly in the chemical reactions and pathways involving an amino acid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
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Allelic Composition: Slc7a5tm1.1Daca/Slc7a5tm1.1Daca,Tg(Tek-cre)12Flv/0
Genetic Background: B6J.Cg-Slc7a5tm1.1Daca Tg(Tek-cre)12Flv

 MP:0013272 abnormal translation "any anomaly in the cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain; translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA; translation ends with the release of a polypeptide chain from the ribosome" [GO:0006412]
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Allelic Composition: Slc7a5tm1.1Daca/Slc7a5tm1.1Daca,Tg(Tek-cre)12Flv/0
Genetic Background: B6J.Cg-Slc7a5tm1.1Daca Tg(Tek-cre)12Flv

 MP:0020358 abnormal inhibitory synapse morphology "any structural anomaly in a synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell" [GO:0060077]
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Allelic Composition: Slc7a5tm1.1Daca/Slc7a5tm1.1Daca,Tg(Tek-cre)12Flv/0
Genetic Background: B6J.Cg-Slc7a5tm1.1Daca Tg(Tek-cre)12Flv

 MP:0020361 abnormal symmetric synapse morphology "any structurla anomaly in synapse that lacks an electron dense postsynaptic specialization; in vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typcially inhibitory" [GO:0032280]
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Allelic Composition: Slc7a5tm1.1Daca/Slc7a5tm1.1Daca,Tg(Tek-cre)12Flv/0
Genetic Background: B6J.Cg-Slc7a5tm1.1Daca Tg(Tek-cre)12Flv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010095 P10852 / Slc3a2 / solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 / P08195* / solute carrier family 3 member 2*  / complex






 

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