ENSMUSG00000010095


Mus musculus

Features
Gene ID: ENSMUSG00000010095
  
Biological name :Slc3a2
  
Synonyms : P10852 / Slc3a2 / solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
  
Possible biological names infered from orthology : P08195 / solute carrier family 3 member 2
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 8706882
Gene end: 8723369
  
Corresponding Affymetrix probe sets: 10465772 (MoGene1.0st)   1425364_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130194
Ensembl peptide - ENSMUSP00000146080
Ensembl peptide - ENSMUSP00000146036
Ensembl peptide - ENSMUSP00000146016
Ensembl peptide - ENSMUSP00000145974
Ensembl peptide - ENSMUSP00000145892
Ensembl peptide - ENSMUSP00000145809
Ensembl peptide - ENSMUSP00000010239
NCBI entrez gene - 17254     See in Manteia.
MGI - MGI:96955
RefSeq - XM_017318078
RefSeq - NM_001161413
RefSeq - NM_008577
RefSeq - XM_006526733
RefSeq Peptide - NP_032603
RefSeq Peptide - NP_001154885
swissprot - P10852
swissprot - A0A0U1RPQ7
swissprot - A0A0U1RPK4
swissprot - A0A0U1RPG5
swissprot - A0A0U1RP32
swissprot - A0A0U1RP98
swissprot - A0A0U1RPL8
Ensembl - ENSMUSG00000010095
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc3a2aENSDARG00000036427Danio rerio
 slc3a2bENSDARG00000037012Danio rerio
 zgc:158423ENSDARG00000055791Danio rerio
 P08195ENSG00000168003Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91WV7 / Slc3a1 / Neutral and basic amino acid transport protein rBAT / Q07837* / solute carrier family 3 member 1*ENSMUSG0000002413123


Protein motifs (from Interpro)
Interpro ID Name
 IPR006047  Glycosyl hydrolase, family 13, catalytic domain
 IPR017853  Glycoside hydrolase superfamily
 IPR031984  Solute carrier family 3 member 2, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0015827 tryptophan transport ISS
 biological_processGO:0043330 response to exogenous dsRNA ISO
 biological_processGO:1903801 L-leucine import across plasma membrane ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0003725 double-stranded RNA binding ISO
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015175 neutral amino acid transmembrane transporter activity ISS
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Basigin interactions
Amino acid transport across the plasma membrane
Tryptophan catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Srftm2Nor/Srftm2Nor,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc3a2tm1.1Yait/Slc3a2tm1.1Yait,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrSlc

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1Yai
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc3a2tm1.1Yait/Slc3a2tm1.1Yait,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrSlc

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc3a2tm1.1Yait/Slc3a2tm1.1Yait,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrSlc

 MP:0002454 abnormal macrophage antigen presentation "impairment of these phagocytic cells to process and present antigen to T lymphocytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Foxp4tm1Eem/Foxp4tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Srftm2Nor/Srftm2Nor,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008099 abnormal plasma cell differentiation "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008113 abnormal macrophage differentiation "atypical production of or inability to produce the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc3a2tm1.1Yait/Slc3a2tm1.1Yait,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrSlc

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1Yai
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr

 MP:0010181 decreased susceptibility to weight loss "smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000958 Q9Z1K8 / Slc7a7 / Y+L amino acid transporter 1 / Q9UM01* / solute carrier family 7 member 7*  / complex
 ENSMUSG00000030495 P63115 / Slc7a10 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 / Q9NS82* / solute carrier family 7 member 10*  / complex
 ENSMUSG00000040010 Q9Z127 / Slc7a5 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 / Q01650* / solute carrier family 7 member 5*  / complex
 ENSMUSG00000030492 Q9QXA6 / Slc7a9 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 / P82251* / solute carrier family 7 member 9*  / complex
 ENSMUSG00000022180 Q9QXW9 / Slc7a8 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 / Q9UHI5* / solute carrier family 7 member 8*  / complex
 ENSMUSG00000031904 Q8BGK6 / Slc7a6 / Mus musculus solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (Slc7a6), transcript variant 4, mRNA. / Q92536* / solute carrier family 7 member 6*  / complex
 ENSMUSG00000027737 Q9WTR6 / Slc7a11 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 / Q9UPY5* / solute carrier family 7 member 11*  / complex






 

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