ENSMUSG00000022180


Mus musculus

Features
Gene ID: ENSMUSG00000022180
  
Biological name :Slc7a8
  
Synonyms : Q9QXW9 / Slc7a8 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
  
Possible biological names infered from orthology : Q9UHI5 / solute carrier family 7 member 8
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C2
Gene start: 54722209
Gene end: 54781946
  
Corresponding Affymetrix probe sets: 10419854 (MoGene1.0st)   1417929_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022787
NCBI entrez gene - 50934     See in Manteia.
MGI - MGI:1355323
RefSeq - XM_011245114
RefSeq - NM_016972
RefSeq - XM_006519250
RefSeq Peptide - NP_058668
swissprot - Q9QXW9
Ensembl - ENSMUSG00000022180
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc7a8aENSDARG00000075831Danio rerio
 slc7a8bENSDARG00000054343Danio rerio
 Q9UHI5ENSG00000092068Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P63115 / Slc7a10 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 / Q9NS82* / solute carrier family 7 member 10*ENSMUSG0000003049565
Q9Z127 / Slc7a5 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 / Q01650* / solute carrier family 7 member 5*ENSMUSG0000004001048
Q8BGK6 / Slc7a6 / Mus musculus solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (Slc7a6), transcript variant 4, mRNA. / Q92536* / solute carrier family 7 member 6*ENSMUSG0000003190446
Q9Z1K8 / Slc7a7 / Y+L amino acid transporter 1 / Q9UM01* / solute carrier family 7 member 7*ENSMUSG0000000095844
Q9WTR6 / Slc7a11 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 / Q9UPY5* / solute carrier family 7 member 11*ENSMUSG0000002773739
Q9QXA6 / Slc7a9 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 / P82251* / solute carrier family 7 member 9*ENSMUSG0000003049239
Slc7a15 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 15ENSMUSG0000002060035
Q91WN3 / Slc7a13 / Solute carrier family 7 member 13 / Q8TCU3*ENSMUSG0000004105227
Slc7a12 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 12ENSMUSG0000003971022


Protein motifs (from Interpro)
Interpro ID Name
 IPR002293  Amino acid/polyamine transporter I
 IPR004760  L-type amino acid transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003333 amino acid transmembrane transport IEA
 biological_processGO:0006865 amino acid transport ISO
 biological_processGO:0015695 organic cation transport IEA
 biological_processGO:0015804 neutral amino acid transport IBA
 biological_processGO:0015807 L-amino acid transport IDA
 biological_processGO:0015837 amine transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1901998 toxin transport IEA
 biological_processGO:1902475 L-alpha-amino acid transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0005275 amine transmembrane transporter activity ISA
 molecular_functionGO:0015101 organic cation transmembrane transporter activity IEA
 molecular_functionGO:0015171 amino acid transmembrane transporter activity IEA
 molecular_functionGO:0015175 neutral amino acid transmembrane transporter activity IBA
 molecular_functionGO:0015179 L-amino acid transmembrane transporter activity IDA
 molecular_functionGO:0015297 antiporter activity IBA
 molecular_functionGO:0019534 toxin transmembrane transporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Basigin interactions
Amino acid transport across the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
Show

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010095 P10852 / Slc3a2 / solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 / P08195* / solute carrier family 3 member 2*  / complex






 

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