ENSMUSG00000000958


Mus musculus

Features
Gene ID: ENSMUSG00000000958
  
Biological name :Slc7a7
  
Synonyms : Q9Z1K8 / Slc7a7 / Y+L amino acid transporter 1
  
Possible biological names infered from orthology : Q9UM01 / solute carrier family 7 member 7
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C2
Gene start: 54369442
Gene end: 54417780
  
Corresponding Affymetrix probe sets: 10419744 (MoGene1.0st)   1417392_a_at (Mouse Genome 430 2.0 Array)   1447181_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154208
Ensembl peptide - ENSMUSP00000153917
Ensembl peptide - ENSMUSP00000154352
Ensembl peptide - ENSMUSP00000154533
Ensembl peptide - ENSMUSP00000000984
Ensembl peptide - ENSMUSP00000142587
Ensembl peptide - ENSMUSP00000142710
Ensembl peptide - ENSMUSP00000142826
Ensembl peptide - ENSMUSP00000143091
Ensembl peptide - ENSMUSP00000143743
NCBI entrez gene - 20540     See in Manteia.
MGI - MGI:1337120
RefSeq - XM_011245000
RefSeq - XM_006518746
RefSeq - XM_006518748
RefSeq - XM_006518751
RefSeq - XM_006518752
RefSeq - XM_006518753
RefSeq - XM_006518754
RefSeq - XM_006518755
RefSeq - NM_001253679
RefSeq - NM_001253680
RefSeq - NM_011405
RefSeq Peptide - NP_035535
RefSeq Peptide - NP_001240608
RefSeq Peptide - NP_001240609
swissprot - A0A0G2JE10
swissprot - Q9Z1K8
swissprot - A0A0G2JEB8
swissprot - A0A0G2JEM2
Ensembl - ENSMUSG00000000958
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc7a7ENSDARG00000055226Danio rerio
 Q9UM01ENSG00000155465Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BGK6 / Slc7a6 / Mus musculus solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (Slc7a6), transcript variant 4, mRNA. / Q92536* / solute carrier family 7 member 6*ENSMUSG0000003190470
Q9Z127 / Slc7a5 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 / Q01650* / solute carrier family 7 member 5*ENSMUSG0000004001047
Q9QXW9 / Slc7a8 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 / Q9UHI5* / solute carrier family 7 member 8*ENSMUSG0000002218046
P63115 / Slc7a10 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 / Q9NS82* / solute carrier family 7 member 10*ENSMUSG0000003049543
Q9WTR6 / Slc7a11 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 / Q9UPY5* / solute carrier family 7 member 11*ENSMUSG0000002773741
Q9QXA6 / Slc7a9 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 / P82251* / solute carrier family 7 member 9*ENSMUSG0000003049240
Slc7a15 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 15ENSMUSG0000002060034
Q91WN3 / Slc7a13 / Solute carrier family 7 member 13 / Q8TCU3*ENSMUSG0000004105230
Slc7a12 / solute carrier family 7 (cationic amino acid transporter, y+ system), member 12ENSMUSG0000003971025


Protein motifs (from Interpro)
Interpro ID Name
 IPR002293  Amino acid/polyamine transporter I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000821 regulation of arginine metabolic process IMP
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902475 L-alpha-amino acid transmembrane transport IEA
 biological_processGO:1990822 basic amino acid transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0015174 basic amino acid transmembrane transporter activity IMP
 molecular_functionGO:0015179 L-amino acid transmembrane transporter activity IBA
 molecular_functionGO:0015297 antiporter activity IBA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Basigin interactions
Amino acid transport across the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
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Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
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Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0005309 increased circulating ammonia level "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263]
Show

Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Runx1tm1Yg/Runx1tm2Spe
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010095 P10852 / Slc3a2 / solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 / P08195* / solute carrier family 3 member 2*  / complex






 

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