ENSMUSG00000024268


Mus musculus

Features
Gene ID: ENSMUSG00000024268
  
Biological name :Celf4
  
Synonyms : Celf4 / CUGBP Elav-like family member 4 / Q7TSY6
  
Possible biological names infered from orthology : Q9BZC1
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A2
Gene start: 25477632
Gene end: 25754157
  
Corresponding Affymetrix probe sets: 10457895 (MoGene1.0st)   1426929_at (Mouse Genome 430 2.0 Array)   1426930_at (Mouse Genome 430 2.0 Array)   1452240_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153706
Ensembl peptide - ENSMUSP00000153258
Ensembl peptide - ENSMUSP00000153326
Ensembl peptide - ENSMUSP00000025117
Ensembl peptide - ENSMUSP00000111483
Ensembl peptide - ENSMUSP00000153226
NCBI entrez gene - 108013     See in Manteia.
MGI - MGI:1932407
RefSeq - XM_017317802
RefSeq - NM_001146292
RefSeq - NM_001146293
RefSeq - NM_001146294
RefSeq - NM_001174074
RefSeq - NM_133195
RefSeq - XM_017317795
RefSeq - XM_017317796
RefSeq - XM_017317797
RefSeq - XM_017317798
RefSeq - XM_017317799
RefSeq - XM_017317800
RefSeq - XM_017317801
RefSeq - XM_006525508
RefSeq - XM_006525510
RefSeq - XM_006525511
RefSeq - XM_006525512
RefSeq - XM_006525513
RefSeq - XM_006525514
RefSeq - XM_006525515
RefSeq - XM_006525516
RefSeq - XM_006525517
RefSeq - XM_006525518
RefSeq - XM_006525520
RefSeq - XM_011246805
RefSeq - XM_017317782
RefSeq - XM_017317783
RefSeq - XM_017317784
RefSeq - XM_017317785
RefSeq - XM_017317786
RefSeq - XM_017317787
RefSeq - XM_017317788
RefSeq - XM_017317789
RefSeq - XM_017317790
RefSeq - XM_017317791
RefSeq - XM_017317792
RefSeq - XM_017317793
RefSeq - XM_017317794
RefSeq Peptide - NP_001139764
RefSeq Peptide - NP_001139765
RefSeq Peptide - NP_001139766
RefSeq Peptide - NP_001167545
RefSeq Peptide - NP_573458
swissprot - Q7TSY6
swissprot - A0A286YE56
Ensembl - ENSMUSG00000024268
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01018956.1ENSDARG00000114049Danio rerio
 CELF4ENSGALG00000002413Gallus gallus
 CELF4ENSG00000101489Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Celf3 / Q8CIN6 / Mus musculus CUGBP, Elav-like family member 3 (Celf3), transcript variant 8, mRNA. / Q5SZQ8* / CUGBP Elav-like family member 3*ENSMUSG0000002813766
Celf6 / Q7TN33 / CUGBP Elav-like family member 6 / Q96J87* / AC009690.3*ENSMUSG0000003229765
Celf5 / CUGBP, Elav-like family member 5 / Q8N6W0*ENSMUSG0000003481850
Celf1 / P28659 / CUGBP Elav-like family member 1 / Q92879*ENSMUSG0000000550646
Celf2 / Q9Z0H4 / CUGBP Elav-like family member 2 / O95319*ENSMUSG0000000210746


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR034648  CELF-3/4/5/6, RNA recognition motif 1
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000380 alternative mRNA splicing, via spliceosome IEA
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IEA
 biological_processGO:0006376 mRNA splice site selection IDA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0048025 negative regulation of mRNA splicing, via spliceosome IMP
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IEA
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential IMP
 biological_processGO:1902866 regulation of retina development in camera-type eye IEP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0036002 pre-mRNA binding IEA
 molecular_functionGO:0042835 BRE binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Nsun7Ste5Jcs1/Nsun7Ste5Jcs1
Genetic Background: involves: C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Nsun7Ste5Jcs1/Nsun7Ste5Jcs1
Genetic Background: involves: C57BL/6

Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Nsun7Ste5Jcs1/Nsun7Ste5Jcs1
Genetic Background: involves: C57BL/6

 MP:0001650 electrically induced seizures "high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
Show

Allelic Composition: Nsun7Ste5Jcs1/Nsun7Ste5Jcs1
Genetic Background: involves: C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nsun7Ste5Jcs1/Nsun7Ste5Jcs1
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: C57BL/6J

Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: C57BL/6J * EL/EFrkJ

Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: A/J * C57BL/6J

Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: BALB/cByJ * C57BL/6J

Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0003686 abnormal eye muscle morphology "malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: C57BL/6J

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Nsun7Ste5Jcs1/Nsun7Ste5Jcs1
Genetic Background: involves: C57BL/6

 MP:0008806 increased circulating amylase level "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Celf4Ff/Celf4Ff
Genetic Background: involves: C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0011683 dual inferior vena cava "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0013877 abnormal ductus venosus valve morphology "any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0013971 blood in lymph vessels 
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0013986 abnormal vitelline vein topology "abnormal position of the paired veins that carry blood from the yolk sac back to the embryo" [MGI:csmith]
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0014004 absent basilar artery segment 
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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