ENSMUSG00000024835


Mus musculus

Features
Gene ID: ENSMUSG00000024835
  
Biological name :Coro1b
  
Synonyms : Coro1b / Coronin-1B / Q9WUM3
  
Possible biological names infered from orthology : Q9BR76
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 4148619
Gene end: 4154035
  
Corresponding Affymetrix probe sets: 10460359 (MoGene1.0st)   1448351_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008893
Ensembl peptide - ENSMUSP00000118450
NCBI entrez gene - 23789     See in Manteia.
MGI - MGI:1345963
RefSeq - XM_006531741
RefSeq - XM_006531742
RefSeq - NM_011778
RefSeq Peptide - NP_035908
swissprot - Q9WUM3
swissprot - D3YUG6
swissprot - A2RS22
Ensembl - ENSMUSG00000024835
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 coro1bENSDARG00000008660Danio rerio
 CORO1BENSG00000172725Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Coro1c / Q9WUM4 / Coronin-1C / Q9ULV4*ENSMUSG0000000453073
Coro6 / Q920M5 / Coronin-6 / Q6QEF8*ENSMUSG0000002083668
Coro1a / O89053 / Coronin-1A / P31146*ENSMUSG0000003070762
Coro2a / Q8C0P5 / Coronin-2A / Q92828*ENSMUSG0000002833742
Coro2b / Q8BH44 / Coronin-2B / Q9UQ03*ENSMUSG0000004172942
Coro7 / Q9D2V7 / Coronin-7 / P57737* / CORO7-PAM16* / CORO7-PAM16 readthrough*ENSMUSG0000003963732


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015048  Domain of unknown function DUF1899
 IPR015505  Coronin
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR027340  Coronin 1B
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0031529 ruffle organization ISO
 biological_processGO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation ISO
 biological_processGO:0035767 endothelial cell chemotaxis ISO
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus ISO
 biological_processGO:0042060 wound healing ISO
 biological_processGO:0051017 actin filament bundle assembly ISO
 biological_processGO:0071672 negative regulation of smooth muscle cell chemotaxis ISO
 biological_processGO:0090135 actin filament branching ISO
 biological_processGO:1902463 protein localization to cell leading edge ISO
 biological_processGO:2000394 positive regulation of lamellipodium morphogenesis ISO
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IBA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0071933 Arp2/3 complex binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0008764 increased mast cell degranulation "increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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