ENSMUSG00000030707


Mus musculus

Features
Gene ID: ENSMUSG00000030707
  
Biological name :Coro1a
  
Synonyms : Coro1a / Coronin-1A / O89053
  
Possible biological names infered from orthology : P31146
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 126699773
Gene end: 126707787
  
Corresponding Affymetrix probe sets: 10568024 (MoGene1.0st)   1416246_a_at (Mouse Genome 430 2.0 Array)   1435288_at (Mouse Genome 430 2.0 Array)   1455269_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133555
Ensembl peptide - ENSMUSP00000117931
Ensembl peptide - ENSMUSP00000134123
Ensembl peptide - ENSMUSP00000146177
Ensembl peptide - ENSMUSP00000032949
Ensembl peptide - ENSMUSP00000101972
Ensembl peptide - ENSMUSP00000115960
NCBI entrez gene - 12721     See in Manteia.
MGI - MGI:1345961
RefSeq - XM_006507285
RefSeq - NM_001301374
RefSeq - NM_009898
RefSeq - XM_006507284
RefSeq Peptide - NP_001288303
RefSeq Peptide - NP_034028
swissprot - A0A0U1RPY8
swissprot - O89053
swissprot - D3YXM2
swissprot - G3UX53
swissprot - D3YW57
swissprot - G3UYK8
swissprot - Q3U1N0
Ensembl - ENSMUSG00000030707
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 coro1aENSDARG00000054610Danio rerio
 CORO1AENSG00000102879Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Coro6 / Q920M5 / Coronin-6 / Q6QEF8*ENSMUSG0000002083666
Coro1b / Q9WUM3 / Coronin-1B / Q9BR76*ENSMUSG0000002483565
Coro1c / Q9WUM4 / Coronin-1C / Q9ULV4*ENSMUSG0000000453064
Coro2b / Q8BH44 / Coronin-2B / Q9UQ03*ENSMUSG0000004172944
Coro2a / Q8C0P5 / Coronin-2A / Q92828*ENSMUSG0000002833744
Coro7 / Q9D2V7 / Coronin-7 / P57737* / CORO7-PAM16* / CORO7-PAM16 readthrough*ENSMUSG0000003963734


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015048  Domain of unknown function DUF1899
 IPR015049  Trimerisation motif
 IPR015505  Coronin
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR029508  Coronin 1A
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001845 phagolysosome assembly IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0006909 phagocytosis ISO
 biological_processGO:0007015 actin filament organization IMP
 biological_processGO:0008064 regulation of actin polymerization or depolymerization IMP
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0030036 actin cytoskeleton organization ISO
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030595 leukocyte chemotaxis IEA
 biological_processGO:0030833 regulation of actin filament polymerization IMP
 biological_processGO:0031339 negative regulation of vesicle fusion IMP
 biological_processGO:0031589 cell-substrate adhesion ISO
 biological_processGO:0032796 uropod organization IMP
 biological_processGO:0032956 regulation of actin cytoskeleton organization ISO
 biological_processGO:0034097 response to cytokine IMP
 biological_processGO:0038180 nerve growth factor signaling pathway IGI
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0043320 natural killer cell degranulation ISO
 biological_processGO:0043524 negative regulation of neuron apoptotic process IGI
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0050870 positive regulation of T cell activation IMP
 biological_processGO:0050918 positive chemotaxis ISO
 biological_processGO:0051126 negative regulation of actin nucleation ISO
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IGI
 biological_processGO:0061502 early endosome to recycling endosome transport IMP
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 cellular_componentGO:0001772 immunological synapse ISO
 cellular_componentGO:0001891 phagocytic cup ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium ISO
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton ISO
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0045335 phagocytic vesicle ISO
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003785 actin monomer binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008092 cytoskeletal protein binding IMP
 molecular_functionGO:0032036 myosin heavy chain binding ISO
 molecular_functionGO:0042802 identical protein binding IGI
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding ISO
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pnpi/Pnpi
Genetic Background: involves: C3H/HeHa * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Coro1aLmb3-MRL/MpScr/Coro1aLmb3-MRL/MpScr
Genetic Background: B6.MRL-Coro1aMRL/MpScr Faslpr

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Coro1aptcd/Coro1aptcd
Genetic Background: B6.CTS-Coro1aptcd

Allelic Composition: Coro1aptcd/Coro1atm1Achn
Genetic Background: B6.Cg-Coro1aptcd Coro1atm1Achn

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Coro1akoy/Coro1akoy
Genetic Background: C57BL/6-Coro1akoy

Allelic Composition: Coro1atm1Achn/Coro1atm1Achn
Genetic Background: B6.129X1-Coro1atm1Achn

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pnpi/Pnpi
Genetic Background: involves: C3H/HeHa * C57BL/6J

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pnpi/Pnpi
Genetic Background: involves: C3H/HeHa * C57BL/6J

Allelic Composition: Coro1aptcd/Coro1aptcd
Genetic Background: B6.CTS-Coro1aptcd

Allelic Composition: Coro1aptcd/Coro1atm1Achn
Genetic Background: B6.Cg-Coro1aptcd Coro1atm1Achn

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Coro1aLmb3-MRL/MpScr/Coro1aLmb3-MRL/MpScr
Genetic Background: B6.MRL-Coro1aMRL/MpScr Faslpr

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pnpi/Pnpi
Genetic Background: involves: C3H/HeHa * C57BL/6J

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Coro1aptcd/Coro1aptcd
Genetic Background: B6.CTS-Coro1aptcd

Allelic Composition: Coro1aptcd/Coro1atm1Achn
Genetic Background: B6.Cg-Coro1aptcd Coro1atm1Achn

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk8ip3tm1.1Ysok/Mapk8ip3tm1.1Ysok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Coro1akoy/Coro1akoy
Genetic Background: C57BL/6-Coro1akoy

Allelic Composition: Coro1aptcd/Coro1atm1Achn
Genetic Background: B6.Cg-Coro1aptcd Coro1atm1Achn

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Coro1aLmb3-MRL/MpScr/Coro1aLmb3-MRL/MpScr
Genetic Background: B6.MRL-Coro1aMRL/MpScr Faslpr

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003726 decreased autoantibody level "reduced level of antibodies to self-antigens present in the sera" [acv:Alicia Valenzuela, Genetic Resources Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Coro1aLmb3-MRL/MpScr/Coro1aLmb3-MRL/MpScr
Genetic Background: B6.MRL-Coro1aMRL/MpScr Faslpr

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Pnpi/Pnpi
Genetic Background: involves: C3H/HeHa * C57BL/6J

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Coro1aLmb3-MRL/MpScr/Coro1aLmb3-MRL/MpScr
Genetic Background: B6.MRL-Coro1aMRL/MpScr Faslpr

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Coro1aLmb3-MRL/MpScr/Coro1aLmb3-MRL/MpScr
Genetic Background: B6.MRL-Coro1aMRL/MpScr Faslpr

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Coro1aLmb3-MRL/MpScr/Coro1aLmb3-MRL/MpScr
Genetic Background: B6.MRL-Coro1aMRL/MpScr Faslpr

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Coro1aLmb3-MRL/MpScr/Coro1aLmb3-MRL/MpScr
Genetic Background: B6.MRL-Coro1aMRL/MpScr Faslpr

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pnpi/Pnpi
Genetic Background: involves: C3H/HeHa * C57BL/6J

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pnpi/Pnpi
Genetic Background: involves: C3H/HeHa * C57BL/6J

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Coro1aptcd/Coro1aptcd
Genetic Background: B6.CTS-Coro1aptcd

Allelic Composition: Coro1atm1Achn/Coro1atm1Achn
Genetic Background: B6.129X1-Coro1atm1Achn

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Coro1atm1Jpie/Coro1atm1Jpie
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Coro1aptcd/Coro1aptcd
Genetic Background: B6.CTS-Coro1aptcd

Allelic Composition: Coro1akoy/Coro1akoy
Genetic Background: C57BL/6-Coro1akoy

Allelic Composition: Coro1aptcd/Coro1atm1Achn
Genetic Background: B6.Cg-Coro1aptcd Coro1atm1Achn

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Coro1atm1Jpie/Coro1atm1Jpie
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Coro1aptcd/Coro1aptcd
Genetic Background: B6.CTS-Coro1aptcd

Allelic Composition: Coro1akoy/Coro1akoy
Genetic Background: C57BL/6-Coro1akoy

Allelic Composition: Coro1aptcd/Coro1atm1Achn
Genetic Background: B6.Cg-Coro1aptcd Coro1atm1Achn

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

Allelic Composition: Coro1atm1Achn/Coro1atm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Coro1atm1Jpie/Coro1atm1Jpie
Genetic Background: involves: 129 * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

Allelic Composition: Coro1atm1Achn/Coro1atm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0008764 increased mast cell degranulation "increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

Allelic Composition: Coro1atm1Achn/Coro1atm1Achn
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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