| MP:0000774 | reduced brain size | "smaller appearance of the brain" [J:35802] |
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Allelic Composition: Bhlhe22tm1Gan/Bhlhe22tm1Gan
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0000778 | abnormal tract | |
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Allelic Composition: Bhlhe22tm1Gan/Bhlhe22tm1Gan
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Bhlhe22tm1Gan/Bhlhe22tm1Gan
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0000859 | abnormal somatosensory cortex morphology | "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bhlhe22tm1Gan/Bhlhe22tm1Gan
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0000861 | disorganized barrel cortex | "derangement of the pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [Principles of Neural Science:ISBN 0-8385-8034-3, J:64064] |
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Allelic Composition: Bhlhe22tm1Gan/Bhlhe22tm1Gan
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0000937 | abnormal motor neuron morphology | "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Bhlhe22tm1Gan/Bhlhe22tm1Gan
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001212 | skin lesions | "focal patches of inflammation on the skin" [J:30162] |
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Allelic Composition: Nppclbab/Nppclbab
Genetic Background: B6.PL-Nppclbab/GrsrJ
Allelic Composition: Bhlhe22tm1Meg/Bhlhe22tm1Meg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)
Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129/Sv
Allelic Composition: Bhlhe22tm1Meg/Bhlhe22tm1Meg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Bhlhe22tm1Meg/Bhlhe22tm1Meg,Cdh11tm1Mta/Cdh11tm1Mta
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Nppclbab/Nppclbab
Genetic Background: B6.PL-Nppclbab/GrsrJ
Allelic Composition: Bhlhe22tm1Gan/Bhlhe22tm1Gan
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001412 | excessive scratching | "compulsive scraping of the skin, usually with the nails" [J:61340] |
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Allelic Composition: Pik3cbtm1Bvan/Pik3cbtm1Bvan,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129/Sv
Allelic Composition: Bhlhe22tm1Meg/Bhlhe22tm1Meg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0001516 | abnormal motor coordination/ balance | "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Casp6tm1.2Xen/Casp6+
Genetic Background: FVB.B6NTac-Casp6tm1.2Xen
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| MP:0002067 | abnormal sensory capabilities/reflexes/nociception | "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pik3cbtm1Bvan/Pik3cbtm1Bvan,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002196 | acallosal | "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bhlhe22tm1Meg/Bhlhe22tm1Meg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J
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| MP:0002735 | abnormal chemical nociception | "abnormal capability to sense pain elicited by chemical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Bhlhe22tm1Meg/Bhlhe22tm1Meg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)
Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129/Sv
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| MP:0002855 | abnormal cochlear ganglion morphology | "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+,Tg(Neurog1-cre)1Jejo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J
Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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| MP:0002878 | abnormal corticospinal tract | "anomaly in the structure or function of the fibers that arise from the cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Smarca4tm1Tich/Smarca4+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129/Sv
Allelic Composition: Bhlhe22tm1Gan/Bhlhe22tm1Gan
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002961 | abnormal axon guidance | "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Bhlhe22tm1Meg/Bhlhe22tm1Meg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0003633 | abnormal nervous system physiology | |
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Allelic Composition: Bhlhe22tm1Meg/Bhlhe22tm1Meg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)
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| MP:0004562 | abnormal inner hair cell synaptic ribbon morphology | "any structural abnormality in the presynaptic active zone of mature cochlear IHCs which usually contain a single synaptic ribbon, i.e. a submicrometer, electron-dense structure tethering synaptic vesicles; each spiral ganglion neuron receives input from only one IHC synapse" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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| MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bhlhe22tm1Meg/Bhlhe22tm1Meg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)
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| MP:0006075 | abnormal retinal cone bipolar cell morphology | "anomalous structure of the retinal bipolar cells that connect to both ganglion and amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623] |
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Allelic Composition: Nppclbab/Nppclbab
Genetic Background: B6.PL-Nppclbab/GrsrJ
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| MP:0006282 | abnormal posterior horn morphology | "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129/Sv
Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor
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| MP:0008106 | decreased amacrine cell number | "reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nppclbab/Nppclbab
Genetic Background: B6.PL-Nppclbab/GrsrJ
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| MP:0008223 | absent hippocampal commissure | "absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bhlhe22tm1Meg/Bhlhe22tm1Meg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J
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| MP:0008227 | absent anterior commissure | "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bhlhe22tm1Meg/Bhlhe22tm1Meg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0008511 | thin retinal inner nuclear layer | "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nppclbab/Nppclbab
Genetic Background: B6.PL-Nppclbab/GrsrJ
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| MP:0008948 | decreased neuron number | "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor
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| MP:0009681 | abnormal pyramidal decussation morphology | "any structural anomaly of the bundles of pyramidal fibers that intercross obliquely over the midline at the lower border region of the medulla oblongata" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bhlhe22tm1Gan/Bhlhe22tm1Gan
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0009682 | abnormal anterior corticospinal tract morphology | "any structural anomaly of the small bundle of corticospinal motor fibers that do not cross the midline at the pyramidal decussation and descend into the anterior funiculus of the spinal cord; the anterior corticospinal tract controls central axial and girdle muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bhlhe22tm1Gan/Bhlhe22tm1Gan
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Bhlhe22tm1Meg/Bhlhe22tm1Meg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Bhlhe22tm1Meg/Bhlhe22tm1Meg,Cdh11tm1Mta/Cdh11tm1Mta
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J
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