ENSMUSG00000045493


Mus musculus

Features
Gene ID: ENSMUSG00000045493
  
Biological name :Bhlhe23
  
Synonyms : Bhlhe23 / Class E basic helix-loop-helix protein 23 / Q8BGW3
  
Possible biological names infered from orthology : basic helix-loop-helix family member e23 / Q8NDY6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H4
Gene start: 180774381
Gene end: 180776900
  
Corresponding Affymetrix probe sets: 10490535 (MoGene1.0st)   1421561_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104506
NCBI entrez gene - 140489     See in Manteia.
MGI - MGI:2153710
RefSeq - NM_080641
RefSeq Peptide - NP_542372
swissprot - Q0VEJ8
swissprot - Q8BGW3
Ensembl - ENSMUSG00000045493
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bhlhe23ENSDARG00000037588Danio rerio
 BHLHE23ENSGALG00000005718Gallus gallus
 Q8NDY6ENSG00000125533Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bhlhe22 / basic helix-loop-helix family member e22 / Q8NFJ8*ENSMUSG0000002512845
Olig2 / Q9EQW6 / oligodendrocyte transcription factor 2 / Q13516*ENSMUSG0000003983033
Olig3 / Q6PFG8 / Oligodendrocyte transcription factor 3 / Q7RTU3*ENSMUSG0000004559128
Olig1 / Q9JKN5 / Oligodendrocyte transcription factor 1 / Q8TAK6*ENSMUSG0000004616024


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032662  Class E basic helix-loop-helix protein 23
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046548 retinal rod cell development IMP
 biological_processGO:0046671 negative regulation of retinal cell programmed cell death IMP
 biological_processGO:0048050 post-embryonic eye morphogenesis IMP
 biological_processGO:0048468 cell development IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bhlhe23tm1Dbra/Bhlhe23+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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