ENSMUSG00000045591


Mus musculus

Features
Gene ID: ENSMUSG00000045591
  
Biological name :Olig3
  
Synonyms : Olig3 / Oligodendrocyte transcription factor 3 / Q6PFG8
  
Possible biological names infered from orthology : Q7RTU3
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A3
Gene start: 19356533
Gene end: 19358604
  
Corresponding Affymetrix probe sets: 10361895 (MoGene1.0st)   1421728_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057106
NCBI entrez gene - 94222     See in Manteia.
MGI - MGI:2149955
RefSeq - NM_053008
RefSeq Peptide - NP_443734
swissprot - Q6PFG8
Ensembl - ENSMUSG00000045591
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OLIG3ENSGALG00000013862Gallus gallus
 OLIG3ENSG00000177468Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Olig2 / Q9EQW6 / oligodendrocyte transcription factor 2 / Q13516*ENSMUSG0000003983052
Bhlhe22 / basic helix-loop-helix family member e22 / Q8NFJ8*ENSMUSG0000002512830
Olig1 / Q9JKN5 / Oligodendrocyte transcription factor 1 / Q8TAK6*ENSMUSG0000004616029
Q8BGW3 / Bhlhe23 / Class E basic helix-loop-helix protein 23 / Q8NDY6* / basic helix-loop-helix family member e23*ENSMUSG0000004549323


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032659  Oligodendrocyte transcription factor 3
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0021520 spinal cord motor neuron cell fate specification IMP
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0097476 spinal cord motor neuron migration IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(B2M)55Hpl/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl/Dvs

Allelic Composition: Olig3tm1(cre)Ynka/Olig3+,Smotm2Amc/Smotm2Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Herc2J/Herc2J
Genetic Background: BALB/cJ-Herc2J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Herc2J/Herc2J
Genetic Background: BALB/cJ-Herc2J

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
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Allelic Composition: Herc2J/Herc2J
Genetic Background: BALB/cJ-Herc2J

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
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Allelic Composition: Casp1tm1Sesh/Casp1+,Casp4del/Casp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Olig3tm1Tre/Olig3tm2(cre/ERT2)Cbm
Genetic Background: Not Specified

 MP:0003684 abnormal inferior olivary complex "any structural abnormality in the capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids; neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex and have been implicated in various functions, such as learning and timing of movements" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Herc2J/Herc2J
Genetic Background: BALB/cJ-Herc2J

 MP:0004165 abnormal lateral geniculate nucleus morphology "any malformation or absence of the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Olig3tm1(cre)Ynka/Olig3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Herc2J/Herc2J
Genetic Background: BALB/cJ-Herc2J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Casp1tm1Sesh/Casp1+,Casp4del/Casp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp1tm1Sesh/Casp1+,Casp4del/Casp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lbx1tm1Cbm/Lbx1tm1Cbm,Olig3tm1Tre/Olig3tm1Tre
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Olig3tm1Qiu/Olig3tm1Qiu
Genetic Background: Not Specified

Allelic Composition: Olig3tm1Tre/Olig3tm2(cre/ERT2)Cbm
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Olig3tm1Qiu/Olig3tm1Qiu
Genetic Background: Not Specified

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Olig3tm1(cre)Ynka/Olig3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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