ENSMUSG00000039830


Mus musculus

Features
Gene ID: ENSMUSG00000039830
  
Biological name :Olig2
  
Synonyms : Olig2 / oligodendrocyte transcription factor 2 / Q9EQW6
  
Possible biological names infered from orthology : Q13516
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C3.3
Gene start: 91225550
Gene end: 91228677
  
Corresponding Affymetrix probe sets: 10436823 (MoGene1.0st)   1416232_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036797
NCBI entrez gene - 50913     See in Manteia.
MGI - MGI:1355331
RefSeq - NM_016967
RefSeq Peptide - NP_058663
swissprot - Q542S0
swissprot - Q9EQW6
Ensembl - ENSMUSG00000039830
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 olig2ENSDARG00000040946Danio rerio
 OLIG2ENSGALG00000031010Gallus gallus
 OLIG2ENSG00000205927Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Olig3 / Q6PFG8 / Oligodendrocyte transcription factor 3 / Q7RTU3*ENSMUSG0000004559144
Olig1 / Q9JKN5 / Oligodendrocyte transcription factor 1 / Q8TAK6*ENSMUSG0000004616026
Bhlhe22 / basic helix-loop-helix family member e22 / Q8NFJ8*ENSMUSG0000002512825
Q8BGW3 / Bhlhe23 / Class E basic helix-loop-helix protein 23 / Q8NDY6* / basic helix-loop-helix family member e23*ENSMUSG0000004549323


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032658  Oligodendrocyte transcription factor 2
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IDA
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0021529 spinal cord oligodendrocyte cell differentiation IGI
 biological_processGO:0021530 spinal cord oligodendrocyte cell fate specification IDA
 biological_processGO:0021778 oligodendrocyte cell fate specification IEA
 biological_processGO:0021794 thalamus development IMP
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0042552 myelination IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IDA
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex ISS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0071837 HMG box domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rettm8(RET)Jmi/Rettm8(RET)Jmi
Genetic Background: involves: 129X1/SvJ * 129S1/Sv * C57BL/6

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rettm8(RET)Jmi/Rettm8(RET)Jmi
Genetic Background: involves: 129X1/SvJ * 129S1/Sv * C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Gt(ROSA)26Sortm1(Hoxa2)Fmr/Gt(ROSA)26Sor+,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rettm8(RET)Jmi/Rettm8(RET)Jmi
Genetic Background: involves: 129X1/SvJ * 129S1/Sv * C57BL/6

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Olig2tm1Qrlu/Olig2tm1Qrlu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Olig2tm1(cre/Esr1*)Htak/Olig2tm1(cre/Esr1*)Htak
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrj * CBA

Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Juptm1Ruiz/Juptm1Ruiz,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Olig2tm1(cre/Esr1*)Htak/Olig2tm1(cre/Esr1*)Htak
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rettm8(RET)Jmi/Rettm8(RET)Jmi
Genetic Background: involves: 129X1/SvJ * 129S1/Sv * C57BL/6

Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And,Tg(Olig2)#Wdr/?
Genetic Background: Not Specified

 MP:0000954 reduced oligodendrocyte progenitor number "fewer cells that differentiate into a type of glial cell in the central nervous system" [J:15108]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Olig2tm1(cre/Esr1*)Htak/Olig2tm1(cre/Esr1*)Htak
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrj * CBA

Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm1(Hoxa2)Fmr/Gt(ROSA)26Sor+,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Ntf3tm2.1Jae/Ntf3tm2Jae,Olig2tm2(cre)Htak/Olig2+
Genetic Background: Not Specified

Allelic Composition: Olig2tm1(cre/Esr1*)Htak/Olig2tm1(cre/Esr1*)Htak
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Olig2tm1(cre/Esr1*)Htak/Olig2tm1(cre/Esr1*)Htak
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

Allelic Composition: Ntf3tm2.1Jae/Ntf3tm2Jae,Olig2tm2(cre)Htak/Olig2+
Genetic Background: Not Specified

Allelic Composition: Olig2tm1(cre/Esr1*)Htak/Olig2tm1(cre/Esr1*)Htak
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myrftm1Barr/Myrftm1Barr,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Myrftm1Barr/Myrftm1Barr,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Rettm8(RET)Jmi/Rettm8(RET)Jmi
Genetic Background: involves: 129X1/SvJ * 129S1/Sv * C57BL/6

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd22tm1Eac/Cd22+,Lyntm1Ard/Lyn+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * 129X1/SvJ

Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sortm1(DTA)Jpmb,Tg(KRT14-cre/ERT)20Efu/?
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

 MP:0002913 abnormal PNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the peripheral nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0003647 absent oligodendrocytes "absence of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Juptm1Ruiz/Juptm1Ruiz,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Olig2tm1(cre/Esr1*)Htak/Olig2tm1(cre/Esr1*)Htak
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrj * CBA

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm2.1Jae/Ntf3tm2Jae,Olig2tm2(cre)Htak/Olig2+
Genetic Background: Not Specified

Allelic Composition: Olig2tm1(cre/Esr1*)Htak/Olig2tm1(cre/Esr1*)Htak
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Olig2tm1(cre/Esr1*)Htak/Olig2tm1(cre/Esr1*)Htak
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0005112 abnormal anterior horn morphology "anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Olig2tm1(cre/Esr1*)Htak/Olig2tm1(cre/Esr1*)Htak
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrj * CBA

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Olig2tm1(cre/Esr1*)Htak/Olig2tm1(cre/Esr1*)Htak
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrj * CBA

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Juptm1Ruiz/Juptm1Ruiz,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * 129X1/SvJ

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Thtm1.1Ich/Thtm1.1Ich
Genetic Background: Not Specified

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0009412 skeletal muscle fiber degeneration "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0009684 abnormal spinal cord lateral motor column morphology "any structural anomaly of the subclasses of motor neurons which innervate muscles in the limb; motor neurons in the lateral motor column are further organized into pools, each of which innervates a specific muscle in the limb" [PMID:8895454 "Tanabe Y, Jessell TM Diversity and pattern in the developing spinal cord. Science. 1996 Nov 15;274(5290):1115-23."]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Juptm1Ruiz/Juptm1Ruiz,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009685 abnormal spinal cord motor column morphology "any structural anomaly of the subclasses of motor neurons which are organized into longitudinally oriented columns that occupy distinct and, in some cases, discontinuous domains along the rostrocaudal axis of the spinal cord; motor neurons within a single column send their axons to a common peripheral target" [PMID:8895454 "Tanabe Y, Jessell TM Diversity and pattern in the developing spinal cord. Science. 1996 Nov 15;274(5290):1115-23."]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Juptm1Ruiz/Juptm1Ruiz,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0009686 abnormal spinal cord medial motor column morphology "any structural anomaly of the subclasses of motor neurons which project their axons to axial muscles that lie close to the vertebral column; motor neurons in the lateral subdivision of the MMC project their axons to body wall muscles" [PMID:8895454 "Tanabe Y, Jessell TM Diversity and pattern in the developing spinal cord. Science. 1996 Nov 15;274(5290):1115-23."]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Juptm1Ruiz/Juptm1Ruiz,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Myrftm1Barr/Myrftm1Barr,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Olig2tm1(cre/Esr1*)Htak/Olig2tm1(cre/Esr1*)Htak
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrj * CBA

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Juptm1Ruiz/Juptm1Ruiz,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Thtm1.1Ich/Thtm1.1Ich
Genetic Background: Not Specified

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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