ENSMUSG00000046160


Mus musculus

Features
Gene ID: ENSMUSG00000046160
  
Biological name :Olig1
  
Synonyms : Olig1 / Oligodendrocyte transcription factor 1 / Q9JKN5
  
Possible biological names infered from orthology : Q8TAK6
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C3.3
Gene start: 91269772
Gene end: 91271933
  
Corresponding Affymetrix probe sets: 10436828 (MoGene1.0st)   1416149_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061408
NCBI entrez gene - 50914     See in Manteia.
MGI - MGI:1355334
RefSeq - NM_016968
RefSeq Peptide - NP_058664
swissprot - Q3UN59
swissprot - Q9JKN5
Ensembl - ENSMUSG00000046160
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 olig1ENSDARG00000040948Danio rerio
 OLIG1ENSG00000184221Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Olig2 / Q9EQW6 / oligodendrocyte transcription factor 2 / Q13516*ENSMUSG0000003983032
Olig3 / Q6PFG8 / Oligodendrocyte transcription factor 3 / Q7RTU3*ENSMUSG0000004559130
Bhlhe22 / basic helix-loop-helix family member e22 / Q8NFJ8*ENSMUSG0000002512823
Q8BGW3 / Bhlhe23 / Class E basic helix-loop-helix protein 23 / Q8NDY6* / basic helix-loop-helix family member e23*ENSMUSG0000004549321


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032657  Oligodendrocyte transcription factor 1
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ryr1tm1Slh/Ryr1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Olig1tm1Wdr/Olig1tm1Wdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And,Tg(Olig2)#Wdr/?
Genetic Background: Not Specified

Allelic Composition: Ezh2tm2Sho/Ezh2tm2Sho,Olig1tm1(cre)Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0000954 reduced oligodendrocyte progenitor number "fewer cells that differentiate into a type of glial cell in the central nervous system" [J:15108]
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Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0003647 absent oligodendrocytes "absence of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0009808 reduced oligodendrocyte number "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0009941 abnormal olfactory bulb interneuron morphology "any structural anomaly of the group of neurons residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" [PMID:18603310]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Olig1tm1And/Olig1tm1And,Olig2tm1And/Olig2tm1And
Genetic Background: involves: 129 * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0011731 decreased myelin sheath thickness "decrease in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0013438 dysmyelination "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [MGI:csmith]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

Allelic Composition: Ezh2tm2Sho/Ezh2tm2Sho,Olig1tm1(cre)Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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