ENSMUSG00000025997


Mus musculus

Features
Gene ID: ENSMUSG00000025997
  
Biological name :Ikzf2
  
Synonyms : Ikzf2 / P81183 / Zinc finger protein Helios
  
Possible biological names infered from orthology : IKAROS family zinc finger 2 / Q9UKS7
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C3
Gene start: 69531214
Gene end: 69687245
  
Corresponding Affymetrix probe sets: 10355312 (MoGene1.0st)   1421643_at (Mouse Genome 430 2.0 Array)   1437542_at (Mouse Genome 430 2.0 Array)   1456956_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139543
Ensembl peptide - ENSMUSP00000139530
Ensembl peptide - ENSMUSP00000140043
Ensembl peptide - ENSMUSP00000141075
Ensembl peptide - ENSMUSP00000140378
Ensembl peptide - ENSMUSP00000140069
Ensembl peptide - ENSMUSP00000027146
NCBI entrez gene - 22779     See in Manteia.
MGI - MGI:1342541
RefSeq - XM_017320399
RefSeq - XM_006495967
RefSeq - XM_006495968
RefSeq - XM_011238504
RefSeq - XM_011238505
RefSeq - XM_011238506
RefSeq - XM_011238508
RefSeq - XM_011238509
RefSeq - NM_011770
RefSeq - XM_006495959
RefSeq - XM_006495961
RefSeq - XM_006495962
RefSeq - XM_006495963
RefSeq - XM_006495964
RefSeq - XM_006495965
RefSeq - XM_006495966
RefSeq Peptide - NP_035900
swissprot - A0A087WQ74
swissprot - A0A087WQ51
swissprot - A0A087WQX2
swissprot - A0A087WNX1
swissprot - P81183
swissprot - A0A087WNY4
Ensembl - ENSMUSG00000025997
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IKZF2ENSDARG00000069111Danio rerio
 IKZF2ENSGALG00000003136Gallus gallus
 IKZF2ENSG00000030419Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ikzf4 / Q8C208 / Mus musculus IKAROS family zinc finger 4 (Ikzf4), transcript variant 3, mRNA. / Q9H2S9* / IKAROS family zinc finger 4*ENSMUSG0000000257855
Ikzf1 / IKAROS family zinc finger 1 / Q13422*ENSMUSG0000001865450
Ikzf3 / O08900 / Zinc finger protein Aiolos / Q9UKT9* / IKAROS family zinc finger 3*ENSMUSG0000001816846
Ikzf5 / Q8BU00 / Zinc finger protein Pegasus / Q9H5V7* / IKAROS family zinc finger 5*ENSMUSG0000004016719


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR026939  At2g23090-like
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rras2Gt(OST361011)Lex/Rras2Gt(OST361011)Lex
Genetic Background: B6.129S5-Rras2Gt(OST361011)Lex

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hexbmpc191H/Hexbmpc191H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Hexbmpc191H/Hexbmpc191H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: AurkaGt(XQ0149)Wtsi/AurkaGt(XQ0149)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
Show

Allelic Composition: Rras2Gt(OST361011)Lex/Rras2Gt(OST361011)Lex
Genetic Background: B6.129S5-Rras2Gt(OST361011)Lex

 MP:0009651 abnormal eyelid development "aberrant formation of the skin folds covering the front of the eyeball" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rras2Gt(OST361011)Lex/Rras2Gt(OST361011)Lex
Genetic Background: B6.129S5-Rras2Gt(OST361011)Lex

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rras2Gt(OST361011)Lex/Rras2Gt(OST361011)Lex
Genetic Background: B6.129S5-Rras2Gt(OST361011)Lex

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rras2Gt(OST361011)Lex/Rras2Gt(OST361011)Lex
Genetic Background: B6.129S5-Rras2Gt(OST361011)Lex

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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