ENSMUSG00000018168


Mus musculus

Features
Gene ID: ENSMUSG00000018168
  
Biological name :Ikzf3
  
Synonyms : Ikzf3 / O08900 / Zinc finger protein Aiolos
  
Possible biological names infered from orthology : IKAROS family zinc finger 3 / Q9UKT9
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 98464902
Gene end: 98546031
  
Corresponding Affymetrix probe sets: 10390640 (MoGene1.0st)   1436649_at (Mouse Genome 430 2.0 Array)   1441088_at (Mouse Genome 430 2.0 Array)   1453378_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099430
NCBI entrez gene - 22780     See in Manteia.
MGI - MGI:1342542
RefSeq - NM_011771
RefSeq - XM_006533204
RefSeq Peptide - NP_035901
swissprot - O08900
Ensembl - ENSMUSG00000018168
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IKZF3ENSGALG00000013481Gallus gallus
 IKZF3ENSG00000161405Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ikzf1 / IKAROS family zinc finger 1 / Q13422*ENSMUSG0000001865452
Ikzf2 / P81183 / Zinc finger protein Helios / Q9UKS7* / IKAROS family zinc finger 2*ENSMUSG0000002599748
Ikzf4 / Q8C208 / Mus musculus IKAROS family zinc finger 4 (Ikzf4), transcript variant 3, mRNA. / Q9H2S9* / IKAROS family zinc finger 4*ENSMUSG0000000257844
Ikzf5 / Q8BU00 / Zinc finger protein Pegasus / Q9H5V7* / IKAROS family zinc finger 5*ENSMUSG0000004016720


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030888 regulation of B cell proliferation IMP
 biological_processGO:0042113 B cell activation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045577 regulation of B cell differentiation IMP
 biological_processGO:0045619 regulation of lymphocyte differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0002491 decreased IgD "less than normal immunoglobulin class D level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0002533 type III hypersensitivity reaction "tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury " [Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0005265 abnormal blood urea nitrogen level "aberrant circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0005387 immune system phenotype 
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btkxid/Btkxid,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129S4/SvJae * CBA/CaHN

Allelic Composition: Btkxid/Y,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129S4/SvJae * CBA/CaHN

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0008185 decreased naive B cell number "reduced number of mature B cells which have not yet been activated by antigen" [CL:0000788, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0010850 increased effector memory CD8-positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0012361 decreased large unstained cell number "decreased number of larger than normal cells which are unstained using routine blood count methodologies; large unstained cells (LUC) are larger than normal lymphocytes, and may be atypical lymphocytes, myeloperoxidase deficient cells or peroxidase negative blasts" [MPD:Molly, PMID:10388493]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0013511 increased CD4-negative NK T cell number "increase in the number of CD4-negative NK T cells" [MGI:Saran]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0013513 decreased memory-marker CD4-negative NK T cell number "reduction in the number of memory-marker CD4-negative NK T cells with a CD44+ CD62L- phenotype" [MGI:Saran]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0013519 decreased CD4-positive NK T cell number "reduction in the number of CD4-positive NK T cells" [MGI:Saran]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0013522 decreased memory-marker CD4-positive NK T cell number "reduction in the number of memory-marker CD4-positive NK T cells with a CD44+ CD62L- phenotype" [MGI:Saran]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0013648 increased CD11b-high dendritic cell number "increase in the number of dendritic cells expressing high levels of CD11b which usually depend on Irf4 for their development" [MGI:Saran, PMID:23516985]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0013669 decreased Ly6C-positive immature NK cell number "reduction in the number of immature NK cells expressing the memory marker Ly6C" [MGI:Saran]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0013675 decreased Ly6C-positive mature NK cell number "reduction in the number of mature NK cells expressing the memory marker Ly6C" [MGI:Saran]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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