Manteia

ENSMUSG00000018654

Mus musculus

Features

Gene ID:	ENSMUSG00000018654

Biological name :	Ikzf1

Synonyms :	IKAROS family zinc finger 1 / Ikzf1

Possible biological names infered from orthology :	Q13422

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	A1
Gene start:	11685003
Gene end:	11772926

Corresponding Affymetrix probe sets:	10374333 (MoGene1.0st) 1421303_at (Mouse Genome 430 2.0 Array) 1436312_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000119960 Ensembl peptide - ENSMUSP00000018798 Ensembl peptide - ENSMUSP00000046974 Ensembl peptide - ENSMUSP00000067372 Ensembl peptide - ENSMUSP00000075992 Ensembl peptide - ENSMUSP00000117958 NCBI entrez gene - 22778 See in Manteia. MGI - MGI:1342540 RefSeq - XM_011243718 RefSeq - NM_001025597 RefSeq - NM_001301863 RefSeq - NM_001301865 RefSeq - NM_001301866 RefSeq - NM_001301868 RefSeq - NM_009578 RefSeq - XM_011243706 RefSeq - XM_011243707 RefSeq - XM_011243708 RefSeq - XM_011243709 RefSeq - XM_011243710 RefSeq - XM_011243711 RefSeq - XM_011243712 RefSeq - XM_011243713 RefSeq - XM_011243714 RefSeq - XM_011243715 RefSeq - XM_011243716 RefSeq - XM_011243717 RefSeq - XM_006514676 RefSeq - XM_006514680 RefSeq - XM_006514682 RefSeq - XM_011243700 RefSeq - XM_011243701 RefSeq - XM_011243702 RefSeq - XM_011243703 RefSeq - XM_011243704 RefSeq - XM_011243705 RefSeq Peptide - NP_001020768 RefSeq Peptide - NP_001288792 RefSeq Peptide - NP_001288794 RefSeq Peptide - NP_001288795 RefSeq Peptide - NP_001288797 RefSeq Peptide - NP_033604 swissprot - Q5SWT6 swissprot - Q5SWT7 swissprot - Q5SWT9 swissprot - Q5SWU0 swissprot - Q8C9X3 swissprot - G5E8H3 Ensembl - ENSMUSG00000018654

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ikzf1	ENSDARG00000013539	Danio rerio
IKZF1	ENSGALG00000013086	Gallus gallus
IKZF1	ENSG00000185811	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ikzf3 / O08900 / Zinc finger protein Aiolos / Q9UKT9* / IKAROS family zinc finger 3*	ENSMUSG00000018168	52
Ikzf2 / P81183 / Zinc finger protein Helios / Q9UKS7* / IKAROS family zinc finger 2*	ENSMUSG00000025997	51
Ikzf4 / Q8C208 / Mus musculus IKAROS family zinc finger 4 (Ikzf4), transcript variant 3, mRNA. / Q9H2S9* / IKAROS family zinc finger 4*	ENSMUSG00000002578	49
Ikzf5 / Q8BU00 / Zinc finger protein Pegasus / Q9H5V7* / IKAROS family zinc finger 5*	ENSMUSG00000040167	19

Protein motifs (from Interpro)

Interpro ID	Name
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR013087	Zinc finger C2H2-type
IPR026939	At2g23090-like
IPR036236	Zinc finger C2H2 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0003676	nucleic acid binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0000238	deficiency of pre-B cells	"lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Grin2a^tm1Nak/Grin2a^tm1Nak,Grin2c^tm1Nak/Grin2c^tm1Nak Genetic Background: involves: 129S/SvEv Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae Allelic Composition: Ikzf1^tm3Kge/Ikzf1^tm3Kge,Tg(CD19-cre/ERT2)1Cgn/? Genetic Background: Not Specified
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae Allelic Composition: Ikzf1^plstc/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JSfdAnu
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0000334	decreased granulocyte number	"fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae
MP:0000600	liver hypoplasia	"reduced size of liver due to decreased cell number " [J:57631]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Grin2a^tm1Nak/Grin2a^tm1Nak,Grin2c^tm1Nak/Grin2c^tm1Nak Genetic Background: involves: 129S/SvEv Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0000693	spleen hyperplasia	"increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0000704	abnormal thymus development	"anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae
MP:0000709	enlarged thymus	"increased size of thymus" [J:50053]	Show Allelic Composition: Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0000711	thymic cortex hypoplasia	"reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Grin2a^tm1Nak/Grin2a^tm1Nak,Grin2c^tm1Nak/Grin2c^tm1Nak Genetic Background: involves: 129S/SvEv Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Ikzf1^plstc/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JSfdAnu
MP:0001601	abnormal myelopoiesis	"atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv
MP:0001655	multifocal hepatic necrosis	"multiple localized areas of pathologic death of cells within, or portions of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0001802	arrested B cell development	"inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Nrg1^tm1Cbm/Nrg1^tm3Cbm,Isl1^tm1(cre)Tmj/Isl1⁺ Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ Allelic Composition: Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae Allelic Composition: Ikzf1^tm1.1Smale/Ikzf1^tm1.1Smale Genetic Background: B6.Cg-Ikzf1^tm1.1Smale Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0001825	arrested T cell development	"failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nrg1^tm1Cbm/Nrg1^tm3Cbm,Isl1^tm1(cre)Tmj/Isl1⁺ Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0002024	T cell derived lymphoma	"group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Ikzf1^tm1(Pax5)Mbu/Ikzf1⁺,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu,Il7r^{tm1.1(icre)Hrr}/Il7r⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL Allelic Composition: Ikzf1^tm3Kge/Ikzf1^tm3Kge,Tg(CD2-icre)4Kio/? Genetic Background: involves: C57BL/10 * CBA/Ca
MP:0002026	leukemia	"progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]	Show Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nrg1^tm1Cbm/Nrg1^tm3Cbm,Isl1^tm1(cre)Tmj/Isl1⁺ Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0002123	abnormal hematopoiesis	"abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grin2a^tm1Nak/Grin2a^tm1Nak,Grin2c^tm1Nak/Grin2c^tm1Nak Genetic Background: involves: 129S/SvEv Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0002144	abnormal B lymphocyte development	"atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ikzf1^tm1Kast/Ikzf1^tm1Kast Genetic Background: involves: 129S2/SvPas Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0002145	abnormal T lymphocyte development	"atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nrg1^tm1Cbm/Nrg1^tm3Cbm,Isl1^tm1(cre)Tmj/Isl1⁺ Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Ikzf1^tm1(Pax5)Mbu/Ikzf1^tm1(Pax5)Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0002343	abnormal lymph node cortex	"anomaly in the outer area of the lymph node that has B and T cell domains" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0002348	abnormal lymph node medulla	"anomaly in the area of the lymph node through which lymph leaves the node; it contains macrophages and antibody-secreting plasma cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0002367	abnormal thymus lobule morphology	"anomalous structure or development of the basic structural unit of the thymus" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0002371	abnormal thymus cortex morphology	"anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0002375	abnormal thymus medulla morphology	"anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0002401	abnormal lymphopoiesis	"atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm2Jas/Thra^tm2Jas Genetic Background: involves: 129/Sv Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0002458	abnormal B cell number	"deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^tm1(Pax5)Mbu/Ikzf1^tm1(Pax5)Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0002459	abnormal B cell physiology	"abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hsd11b1^{tm1a(KOMP)Wtsi}/Hsd11b1⁺ Genetic Background: involves: C57BL/6Jcl * C57BL/6N
MP:0002606	increased basophil count	"higher than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0002831	absent Peyer s patches	"lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0003132	increased number of pre-B cells	"greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0003133	increased number of early pro-B cells	"greater number of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain" [J:91592, smb:Susan M. Bello, Mouse Genome Informatics Curator, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Nrg1^tm1Cbm/Nrg1^tm3Cbm,Isl1^tm1(cre)Tmj/Isl1⁺ Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0003850	abnormal thymocyte activation/response	"anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nrg1^tm1Cbm/Nrg1^tm3Cbm,Isl1^tm1(cre)Tmj/Isl1⁺ Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ Allelic Composition: Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^tm1Kast/Ikzf1^tm1Kast Genetic Background: involves: 129S2/SvPas Allelic Composition: Ikzf1^tm1.1Smale/Ikzf1^tm1.1Smale Genetic Background: B6.Cg-Ikzf1^tm1.1Smale Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0005061	abnormal eosinophil morphology	"structural anomaly of the granular leukocytes having a two-lobed nucleus and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0005068	abnormal NK cell morphology/development	"anomalous structure, differentiation, or number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0005089	decreased double-negative T cell count	"reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0005093	impaired B cell proliferation	"absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^tm1Kast/Ikzf1^tm1Kast Genetic Background: involves: 129S2/SvPas
MP:0005348	increased T cell proliferation	"increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0005425	increased macrophage count	"greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0005461	abnormal dendritic cell morphology/development	"anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ikzf1^tm1(Pax5)Mbu/Ikzf1^tm1(Pax5)Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006410	abnormal common myeloid progenitor cell morphology	"anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0008046	absent NK cells	"absence of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0008070	absent T cells	"absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0008071	absent B cells	"absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae
MP:0008102	lymph node hyperplasia	"overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0008111	abnormal granulocyte differentiaton	"atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0008113	abnormal macrophage differentiation	"atypical production of or inability to produce the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0008124	decreased plasmacytoid dendritic cell number	"reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]	Show Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0008125	abnormal dendritic cell number	"anomaly in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae
MP:0008168	decreased B-1a cell number	"reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]	Show Allelic Composition: Ikzf1^tm1Kast/Ikzf1^tm1Kast Genetic Background: involves: 129S2/SvPas Allelic Composition: Ikzf1^tm1.1Smale/Ikzf1^tm1.1Smale Genetic Background: B6.Cg-Ikzf1^tm1.1Smale
MP:0008170	decreased B-1b cell number	"reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]	Show Allelic Composition: Ikzf1^tm1Kast/Ikzf1^tm1Kast Genetic Background: involves: 129S2/SvPas Allelic Composition: Ikzf1^tm1.1Smale/Ikzf1^tm1.1Smale Genetic Background: B6.Cg-Ikzf1^tm1.1Smale
MP:0008186	increased pro-B cell number	"greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0008187	absent pro-B cells	"absence of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae
MP:0008203	absent B-1a cells	"absence of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]	Show Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae
MP:0008208	decreased pro-B cell number	"reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu,Cd79a^tm1(cre)Reth/Cd79a⁺,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6 * SJL
MP:0008209	decreased pre-B cell number	"reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Ikzf1^tm1.1Smale/Ikzf1^tm1.1Smale Genetic Background: B6.Cg-Ikzf1^tm1.1Smale Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL Allelic Composition: Ikzf1^tm3Kge/Ikzf1^tm3Kge,Tg(CD19-cre/ERT2)1Cgn/? Genetic Background: Not Specified
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc Allelic Composition: Ikzf1^tm1.1Smale/Ikzf1^tm1.1Smale Genetic Background: B6.Cg-Ikzf1^tm1.1Smale Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0008215	decreased immature B cell number	"reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1.1Smale/Ikzf1^tm1.1Smale Genetic Background: B6.Cg-Ikzf1^tm1.1Smale Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0008217	abnormal B cell activation	"any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kast/Ikzf1^tm1Kast Genetic Background: involves: 129S2/SvPas
MP:0008346	increased gamma-delta T cell number	"greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0008351	decreased gamma-delta intraepithelial T cell number	"reduced number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae
MP:0008354	decreased mature gamma-delta T cell number	"reduced number of a mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae
MP:0008463	abnormal peripheral lymph node morphology	"any structural anomaly of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0008465	absent mesenteric lymph nodes	"absence of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae
MP:0008466	enlarged mesenteric lymph nodes	"increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0008475	intermingled spleen red and white pulp	"no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0008477	decreased spleen red pulp amount	"reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0008478	increased spleen white pulp amount	"increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0008482	decreased spleen germinal center number	"reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]	Show Allelic Composition: Ikzf1^tm1Kast/Ikzf1^tm1Kast Genetic Background: involves: 129S2/SvPas
MP:0008498	decreased IgG3 level	"less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kast/Ikzf1^tm1Kast Genetic Background: involves: 129S2/SvPas
MP:0008542	enlarged cervical lymph nodes	"increased size of the lymph nodes found near the neck and shoulders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1⁺ Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0008760	abnormal immunoglobulin heavy chain V(D)J recombination	"any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf3^tm1Mbu/Tcf3^tm1.2Mbu,Tg(Aicda-cre)9Mbu/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
MP:0008781	abnormal B cell apoptosis	"change in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm3Kge/Ikzf1^tm3Kge,Tg(CD19-cre/ERT2)1Cgn/? Genetic Background: Not Specified
MP:0008801	abnormal erythroid progenitor cell morphology	"any structural anomaly of a progenitor cell committed to the erythroid lineage" [CL:0000038]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0008826	abnormal splenic cell ratio	"deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae
MP:0008941	reticulocytopenia	"decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0008973	decreased erythroid progenitor cell number	"reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0009339	decreased splenocyte number	"reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae
MP:0009395	persistence of primitive erythrocytes	"presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0009622	absent inguinal lymph nodes	"absence of the lymph nodes normally located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0009630	absent axillary lymph nodes	"absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae
MP:0009633	absent cervical lymph nodes	"absence of the lymph nodes normally found near the neck and shoulders" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge Genetic Background: involves: 129S4/SvJae
MP:0010130	decreased DN1 thymic pro-T cell number	"reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]	Show Allelic Composition: Ikzf1^tm1.1Smale/Ikzf1^tm1.1Smale Genetic Background: B6.Cg-Ikzf1^tm1.1Smale
MP:0010132	decreased DN2 thymocyte number	"reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806]	Show Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0010134	decreased DN3 thymocyte number	"reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]	Show Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0010336	increased acute lymphoblastic leukemia incidence		Show Allelic Composition: Cd4^sesh/Cd4^sesh Genetic Background: C57BL/6JAnu-Cd4^sesh/Apb
MP:0010373	myeloid hyperplasia	"greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^plstc/Ikzf1⁺ Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0010377	abnormal gut flora balance	"anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Ikzf1^tm1Kge/Ikzf1^tm1Kge Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0011176	abnormal erythroblast morphology	"any structural anomaly of the nucleated precursor of erythrocytes" [ISBN:0-683-40008-8]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0011243	decreased fetal derived definitive erythrocyte cell number	"reduced number of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]	Show Allelic Composition: Ikzf1^plstc/Ikzf1^plstc Genetic Background: C57BL/6JSfdAnu-Ikzf1^plstc
MP:0011400	complete lethality	"all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]	Show Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2.1Smale Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0011816	decreased pre-pro B cell number	"reduced number of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive" [CL:0002045, MGI:csmith]	Show Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ikzf1^tm2.1Smale/Ikzf1^tm2.1Smale Genetic Background: B6.Cg-Ikzf1^tm2.1Smale

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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