ENSMUSG00000026630


Mus musculus

Features
Gene ID: ENSMUSG00000026630
  
Biological name :Batf3
  
Synonyms : Basic leucine zipper transcriptional factor ATF-like 3 / Batf3 / Q9D275
  
Possible biological names infered from orthology : basic leucine zipper ATF-like transcription factor 3 / Q9NR55
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H6
Gene start: 191097847
Gene end: 191108945
  
Corresponding Affymetrix probe sets: 10352717 (MoGene1.0st)   1453076_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027943
NCBI entrez gene - 381319     See in Manteia.
MGI - MGI:1925491
RefSeq - NM_030060
RefSeq Peptide - NP_084336
swissprot - Q9D275
Ensembl - ENSMUSG00000026630
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 batf3ENSDARG00000042577Danio rerio
 BATF3ENSGALG00000035516Gallus gallus
 BATF3ENSG00000123685Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Batf / O35284 / Basic leucine zipper transcriptional factor ATF-like / Q16520* / basic leucine zipper ATF-like transcription factor*ENSMUSG0000003426645
Batf2 / Q8R1H8 / Mus musculus basic leucine zipper transcription factor, ATF-like 2 (Batf2), transcript variant 2, mRNA. / Q8N1L9* / basic leucine zipper ATF-like transcription factor 2*ENSMUSG0000003969936


Protein motifs (from Interpro)
Interpro ID Name
 IPR000837  AP-1 transcription factor
 IPR004827  Basic-leucine zipper domain
 IPR029818  Basic leucine zipper transcriptional factor ATF-like 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043011 myeloid dendritic cell differentiation IMP
 biological_processGO:0097028 dendritic cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm
Genetic Background: involves: 129S6/SvEvTac

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
Show

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008122 decreased myeloid dendritic cell number "reduction in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
Show

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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