ENSMUSG00000034266


Mus musculus

Features
Gene ID: ENSMUSG00000034266
  
Biological name :Batf
  
Synonyms : Basic leucine zipper transcriptional factor ATF-like / Batf / O35284
  
Possible biological names infered from orthology : basic leucine zipper ATF-like transcription factor / Q16520
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: D2
Gene start: 85686669
Gene end: 85709087
  
Corresponding Affymetrix probe sets: 10397359 (MoGene1.0st)   1419410_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040706
NCBI entrez gene - 53314     See in Manteia.
MGI - MGI:1859147
RefSeq - NM_016767
RefSeq Peptide - NP_058047
swissprot - O35284
Ensembl - ENSMUSG00000034266
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 batfENSDARG00000011818Danio rerio
 BATFENSGALG00000010323Gallus gallus
 BATFENSG00000156127Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Batf3 / Q9D275 / Basic leucine zipper transcriptional factor ATF-like 3 / Q9NR55* / basic leucine zipper ATF-like transcription factor 3*ENSMUSG0000002663042
Batf2 / Q8R1H8 / Mus musculus basic leucine zipper transcription factor, ATF-like 2 (Batf2), transcript variant 2, mRNA. / Q8N1L9* / basic leucine zipper ATF-like transcription factor 2*ENSMUSG0000003969937


Protein motifs (from Interpro)
Interpro ID Name
 IPR000837  AP-1 transcription factor
 IPR004827  Basic-leucine zipper domain
 IPR029820  Basic leucine zipper transcriptional factor ATF-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IMP
 biological_processGO:0002320 lymphoid progenitor cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IMP
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0043011 myeloid dendritic cell differentiation IMP
 biological_processGO:0045064 T-helper 2 cell differentiation IMP
 biological_processGO:0045190 isotype switching IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 biological_processGO:0072539 T-helper 17 cell differentiation IMP
 biological_processGO:0072540 T-helper 17 cell lineage commitment IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ehmt2tm1.1Cza/Ehmt2tm1.1Cza,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ehmt2tm1.1Cza/Ehmt2tm1.1Cza,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ehmt2tm1.1Cza/Ehmt2tm1.1Cza,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ehmt2tm1.1Cza/Ehmt2tm1.1Cza,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ehmt2tm1.1Cza/Ehmt2tm1.1Cza,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ehmt2tm1.1Cza/Ehmt2tm1.1Cza,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008179 absent germinal center B cells "absence of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Ehmt2tm1.1Cza/Ehmt2tm1.1Cza,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ehmt2tm1.1Cza/Ehmt2tm1.1Cza,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl

Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

 MP:0008897 decreased IgG2c level "less than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

 MP:0009058 decreased interleukin-21 secretion "reduction in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
Show

Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

 MP:0010187 decreased T follicular helper cell number "reduced number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
Show

Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

 MP:0010220 decreased T-helper 17 cell number "reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
Show

Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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