ENSMUSG00000026872


Mus musculus

Features
Gene ID: ENSMUSG00000026872
  
Biological name :Zeb2
  
Synonyms : Q9R0G7 / Zeb2 / zinc finger E-box binding homeobox 2
  
Possible biological names infered from orthology : O60315
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 44983632
Gene end: 45117395
  
Corresponding Affymetrix probe sets: 10482448 (MoGene1.0st)   1422748_at (Mouse Genome 430 2.0 Array)   1434298_at (Mouse Genome 430 2.0 Array)   1454200_at (Mouse Genome 430 2.0 Array)   1456389_at (Mouse Genome 430 2.0 Array)   1458941_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135393
Ensembl peptide - ENSMUSP00000144637
Ensembl peptide - ENSMUSP00000144552
Ensembl peptide - ENSMUSP00000144421
Ensembl peptide - ENSMUSP00000144406
Ensembl peptide - ENSMUSP00000144197
Ensembl peptide - ENSMUSP00000144141
Ensembl peptide - ENSMUSP00000144075
Ensembl peptide - ENSMUSP00000143976
Ensembl peptide - ENSMUSP00000143841
Ensembl peptide - ENSMUSP00000135491
Ensembl peptide - ENSMUSP00000028229
Ensembl peptide - ENSMUSP00000069685
Ensembl peptide - ENSMUSP00000076111
Ensembl peptide - ENSMUSP00000120130
Ensembl peptide - ENSMUSP00000134747
Ensembl peptide - ENSMUSP00000134849
NCBI entrez gene - 24136     See in Manteia.
MGI - MGI:1344407
RefSeq - XM_017318065
RefSeq - NM_001289521
RefSeq - NM_001355288
RefSeq - NM_001355289
RefSeq - NM_001355290
RefSeq - NM_001355291
RefSeq - NM_015753
RefSeq - XM_006498042
RefSeq - XM_006498043
RefSeq - XM_011239102
RefSeq - XM_017318061
RefSeq - XM_017318063
RefSeq Peptide - NP_001342217
RefSeq Peptide - NP_001342220
RefSeq Peptide - NP_056568
RefSeq Peptide - NP_001342218
RefSeq Peptide - NP_001342219
RefSeq Peptide - NP_001276450
swissprot - A0A0J9YUY9
swissprot - A0A0J9YUI4
swissprot - A0A0J9YUE5
swissprot - A0A0J9YU94
swissprot - A0A0J9YU28
swissprot - A0A0J9YTT5
swissprot - F6X889
swissprot - H3BKH5
swissprot - H9H9S3
swissprot - H3BKR1
swissprot - A0A0J9YVF6
swissprot - Q9R0G7
swissprot - A0A0M3HEP2
swissprot - A0A0J9YV93
swissprot - A0A0J9YV01
Ensembl - ENSMUSG00000026872
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zeb2bENSDARG00000078416Danio rerio
 ZEB2ENSGALG00000040465Gallus gallus
 ZEB2ENSG00000169554Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zeb1 / Q64318 / zinc finger E-box binding homeobox 1 / P37275*ENSMUSG0000002423841
Zfp324 / zinc finger protein 324 / Q6AW86* / O75467* / ZNF324* / ZNF324B* / zinc finger protein 324B*ENSMUSG000000045009


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR008598  Drought induced 19 protein type, zinc-binding domain
 IPR009057  Homeobox-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR026939  At2g23090-like
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007417 central nervous system development IGI
 biological_processGO:0021540 corpus callosum morphogenesis IMP
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0021846 cell proliferation in forebrain IMP
 biological_processGO:0021957 corticospinal tract morphogenesis IMP
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IMP
 biological_processGO:0043507 positive regulation of JUN kinase activity IMP
 biological_processGO:0045636 positive regulation of melanocyte differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048023 positive regulation of melanin biosynthetic process IC
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0048598 embryonic morphogenesis IGI
 biological_processGO:0048668 collateral sprouting IMP
 biological_processGO:0050772 positive regulation of axonogenesis IMP
 biological_processGO:0061373 mammillary axonal complex development IMP
 biological_processGO:0097324 melanocyte migration IMP
 biological_processGO:1902748 positive regulation of lens fiber cell differentiation IMP
 biological_processGO:1903056 regulation of melanosome organization IMP
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IMP
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070412 R-SMAD binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.2Yhi/Zeb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.2Yhi/Zeb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.2Yhi/Zeb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.1Yhi/Zeb2tm1.1Yhi,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.2Yhi/Zeb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zeb1tm2Yhi/Zeb1+,Zeb2tm1.2Yhi/Zeb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hoxc13tm2Mrc/Hoxc13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: L1camtm1Mtei/Y
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Zeb2tm1.1Yhi/Zeb2tm1.1Yhi,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * FVB

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: L1camtm1Mtei/Y
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Zeb2tm1.1Yhi/Zeb2tm1.1Yhi,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * FVB

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kat5tm1Jwl/Kat5+,Tg(IghMyc)22Bri/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129 * C57BL * C57BL/6 * SJL

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.1Yhi/Zeb2tm1.1Yhi,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
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Allelic Composition: Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.1Yhi/Zeb2tm1.1Yhi,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zeb1tm2Yhi/Zeb1+,Zeb2tm1.2Yhi/Zeb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: L1camtm1Mtei/Y
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Zeb2tm1.1Yhi/Zeb2tm1.1Yhi,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * FVB

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.1Yhi/Zeb2tm1.1Yhi,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.1Yhi/Zeb2tm1.1Yhi,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.2Yhi/Zeb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0006342 absent first branchial arch "missing the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad4tm1Rob/Smad4tm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.1Yhi/Zeb2tm1.1Yhi,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Mbd2tm1Bh/Mbd2tm1Bh,Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
Show

Allelic Composition: Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.1Yhi/Zeb2tm1.1Yhi,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0012746 abnormal neural crest cell delamination "any anomaly in the process by which a neural crest cell (NCC) physically dissociates from the neuroepithelium in the dorsal aspect of the neural tube; premigratory NCCs exist within a fully polarized epithelial layer, adjoined by adherens junctions and tight junctions; NCC delamination involves an epithelial-mesenchymal transition (EMT) during which epithelial cells are converted into migratory mesenchymal cells; EMT requires loss of apical-basal cell polarity and dissolution of tight junctions and is accompanied by changes in cytoskeletal organization and a switch in adhesive properties so that cells can separate from the neuroepithelium and emigrate" [MGI:anna]
Show

Allelic Composition: Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0012757 abnormal cranial neural crest cell migration "any anomaly in the migratory path of the cranial neural crest cells (NCCs), which originate in the anterior part of the developing embryo and reside between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [MGI:anna]
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Allelic Composition: Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0013011 absent vagal neural crest cells "absence of the neural crest cells (NCCs) that arise from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7" [MGI:anna, PMID:22016183]
Show

Allelic Composition: Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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