ENSMUSG00000026999


Mus musculus

Features
Gene ID: ENSMUSG00000026999
  
Biological name :Nup35
  
Synonyms : Nucleoporin NUP53 / Nup35 / Q8R4R6
  
Possible biological names infered from orthology : nucleoporin 35 / Q8NFH5
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C3
Gene start: 80617236
Gene end: 80658906
  
Corresponding Affymetrix probe sets: 10473230 (MoGene1.0st)   10567131 (MoGene1.0st)   1426447_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028382
Ensembl peptide - ENSMUSP00000122132
NCBI entrez gene - 69482     See in Manteia.
MGI - MGI:1916732
RefSeq - NM_001190179
RefSeq - NM_027091
RefSeq Peptide - NP_001177108
RefSeq Peptide - NP_081367
swissprot - Q8R4R6
swissprot - A2ATJ2
Ensembl - ENSMUSG00000026999
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nup35ENSDARG00000012222Danio rerio
 ENSGALG00000002689Gallus gallus
 NUP35ENSG00000163002Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm4353 / Q8R4R6 / predicted gene 4353 / NUP35* / Q8NFH5* / nucleoporin 35*ENSMUSG00000091900100


Protein motifs (from Interpro)
Interpro ID Name
 IPR007846  RNA-recognition motif (RRM) Nup35-type domain
 IPR017389  Nucleoporin, NUP53
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006607 NLS-bearing protein import into nucleus IBA
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0006999 nuclear pore organization IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane ISO
 cellular_componentGO:0044613 nuclear pore central transport channel IBA
 cellular_componentGO:0044615 nuclear pore nuclear basket IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0005543 phospholipid binding IBA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001045 abnormal enteric ganglia morphology "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0008802 abnormal intestinal smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue lining the intestine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0009536 abnormal interstitial cell of Cajal morphology "any structural abnormality in the type of cell found in the gastrointestinal tract and serving as a pacemaker that triggers gut contraction; ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumours (GISTs) arise; abnormalities in the ICC network can cause chronic intestinal pseudo-obstruction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:16460275]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0014033 abnormal submucosal gland morphology "any functional anomaly of the mucous-secreting glands located in the dense irregular connective tissue that lines organs and supports the mucosal membrane" [ISBN:0683400088, MGI:csmith]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0014221 increased colon goblet cell number 
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0014231 intestinal mucus accumulation 
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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