Manteia

ENSMUSG00000027655

Mus musculus

Features

Gene ID:	ENSMUSG00000027655

Biological name :	Dhx35

Synonyms :	Dhx35 / probable ATP-dependent RNA helicase DHX35 isoform b

Possible biological names infered from orthology :	DEAH-box helicase 35 / Q9H5Z1

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	H1
Gene start:	158794807
Gene end:	158858214

Corresponding Affymetrix probe sets:	10478169 (MoGene1.0st) 1452693_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000119497 Ensembl peptide - ENSMUSP00000029186 Ensembl peptide - ENSMUSP00000105104 NCBI entrez gene - 71715 See in Manteia. MGI - MGI:1918965 RefSeq - XM_017319264 RefSeq - NM_001291144 RefSeq - NM_145742 RefSeq - XM_006500188 RefSeq Peptide - NP_001278073 RefSeq Peptide - NP_665685 swissprot - A2ACQ1 swissprot - Q8K1G9 swissprot - A2ACP9 Ensembl - ENSMUSG00000027655

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
DHX35	ENSDARG00000063419	Danio rerio
DHX35	ENSGALG00000003658	Gallus gallus
DHX35	ENSG00000101452	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Dhx8 / A2A4P0 / ATP-dependent RNA helicase DHX8 / Q14562* / DEAH-box helicase 8*	ENSMUSG00000034931	47
Dhx16 / DEAH-box helicase 16 / O60231*	ENSMUSG00000024422	46
Dhx38 / DEAH-box helicase 38 / Q92620*	ENSMUSG00000037993	42
Dhx15 / O35286 / Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 / O43143* / DEAH-box helicase 15*	ENSMUSG00000029169	42
Dhx33 / Q80VY9 / Putative ATP-dependent RNA helicase DHX33 / Q9H6R0* / DEAH-box helicase 33*	ENSMUSG00000040620	41
Dhx40 / Q6PE54 / Probable ATP-dependent RNA helicase DHX40 / Q8IX18* / DEAH-box helicase 40*	ENSMUSG00000018425	35
Dhx34 / DExH-box helicase 34 / Q14147*	ENSMUSG00000006019	32
Cltc / Q68FD5 / Mus musculus clathrin, heavy polypeptide (Hc) (Cltc), transcript variant 1, mRNA.	ENSMUSG00000047126	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR001650	Helicase, C-terminal
IPR002464	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
IPR007502	Helicase-associated domain
IPR011709	Domain of unknown function DUF1605
IPR014001	Helicase superfamily 1/2, ATP-binding domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006396	RNA processing	IBA
cellular_component	GO:0005681	spliceosomal complex	IBA
cellular_component	GO:0005737	cytoplasm	IBA
cellular_component	GO:0071013	catalytic step 2 spliceosome	ISO
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003723	RNA binding	IBA
molecular_function	GO:0004004	ATP-dependent RNA helicase activity	IBA
molecular_function	GO:0004386	helicase activity	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016787	hydrolase activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0000161	scoliosis	"lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0000629	absent mammary gland	"missing milk-secreting glands of the breast" [J:18378]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0002633	persistent truncus arteriosis	"complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0003451	absent olfactory bulb	"absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0004158	right aortic arch	"the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0004163	abnormal adenophysis morphology	"any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0004269	abnormal optic cup morphology	"any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0004463	basisphenoid bone foramen	"the presence of one or more holes in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0005157	holoprosencephaly	"presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0008128	abnormal brain internal capsule morphology	"any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0008923	thoracoschisis	"congenital fissure of the chest wall" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0010420	muscular ventricular septal defect	"abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0010589	common truncal valve	"a single outflow tract valve that opens into the truncus arteriosus that is frequently present in cases of truncus arteriosus septation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0013186	abnormal basilar artery morphology	"any structural anomaly of the unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear" [MGI:anna]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0013836	abnormal hypoglossal nerve topology	"abnormal position of the hypoglossal nerve " [MGI:csmith]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0013952	retro-esophageal left subclavian artery		Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0013970	absent connection between subcutaneous lymph vessels and lymph sac		Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0013977	symmetric azygos veins		Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0013981	double lumen aortic arch		Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
MP:0013996	abnormal vertebral artery origin		Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺ Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr