ENSMUSG00000040620


Mus musculus

Features
Gene ID: ENSMUSG00000040620
  
Biological name :Dhx33
  
Synonyms : Dhx33 / Putative ATP-dependent RNA helicase DHX33 / Q80VY9
  
Possible biological names infered from orthology : DEAH-box helicase 33 / Q9H6R0
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B4
Gene start: 70984091
Gene end: 71004437
  
Corresponding Affymetrix probe sets: 10388018 (MoGene1.0st)   1429191_at (Mouse Genome 430 2.0 Array)   1438765_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104167
Ensembl peptide - ENSMUSP00000136782
Ensembl peptide - ENSMUSP00000136913
Ensembl peptide - ENSMUSP00000038018
Ensembl peptide - ENSMUSP00000136051
NCBI entrez gene - 216877     See in Manteia.
MGI - MGI:2445102
RefSeq - XM_011248927
RefSeq - NM_178367
RefSeq - XM_006532927
RefSeq - XM_011248926
RefSeq Peptide - NP_848144
swissprot - A3QK59
swissprot - Q80VY9
swissprot - J3QNQ9
swissprot - K3W4M7
swissprot - J3QJZ5
Ensembl - ENSMUSG00000040620
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhx33ENSDARG00000051785Danio rerio
 DHX33ENSGALG00000001630Gallus gallus
 DHX33ENSG00000005100Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dhx8 / A2A4P0 / ATP-dependent RNA helicase DHX8 / Q14562* / DEAH-box helicase 8*ENSMUSG0000003493145
Dhx16 / DEAH-box helicase 16 / O60231*ENSMUSG0000002442244
Dhx38 / DEAH-box helicase 38 / Q92620*ENSMUSG0000003799342
Dhx35 / probable ATP-dependent RNA helicase DHX35 isoform b / Q9H5Z1* / DEAH-box helicase 35*ENSMUSG0000002765540
Dhx15 / O35286 / Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 / O43143* / DEAH-box helicase 15*ENSMUSG0000002916940
Dhx40 / Q6PE54 / Probable ATP-dependent RNA helicase DHX40 / Q8IX18* / DEAH-box helicase 40*ENSMUSG0000001842536
Dhx34 / DExH-box helicase 34 / Q14147*ENSMUSG0000000601935
Cltc / Q68FD5 / Mus musculus clathrin, heavy polypeptide (Hc) (Cltc), transcript variant 1, mRNA.ENSMUSG0000004712619


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR007502  Helicase-associated domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR011709  Domain of unknown function DUF1605
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006396 RNA processing IBA
 biological_processGO:0006413 translational initiation IDA
 biological_processGO:0032481 positive regulation of type I interferon production IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0045943 positive regulation of transcription by RNA polymerase I IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:1900227 positive regulation of NLRP3 inflammasome complex assembly IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0072559 NLRP3 inflammasome complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000182 rDNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0033613 activating transcription factor binding IPI
 molecular_functionGO:0043023 ribosomal large subunit binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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