ENSMUSG00000018425


Mus musculus

Features
Gene ID: ENSMUSG00000018425
  
Biological name :Dhx40
  
Synonyms : Dhx40 / Probable ATP-dependent RNA helicase DHX40 / Q6PE54
  
Possible biological names infered from orthology : DEAH-box helicase 40 / Q8IX18
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 86768846
Gene end: 86807746
  
Corresponding Affymetrix probe sets: 10389561 (MoGene1.0st)   1428267_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018569
Ensembl peptide - ENSMUSP00000114918
NCBI entrez gene - 67487     See in Manteia.
MGI - MGI:1914737
RefSeq - XM_017314718
RefSeq - NM_026191
RefSeq Peptide - NP_080467
swissprot - Q5SXR4
swissprot - Q6PE54
Ensembl - ENSMUSG00000018425
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhx40ENSDARG00000041586Danio rerio
 DHX40ENSGALG00000005126Gallus gallus
 DHX40ENSG00000108406Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dhx8 / A2A4P0 / ATP-dependent RNA helicase DHX8 / Q14562* / DEAH-box helicase 8*ENSMUSG0000003493138
Dhx16 / DEAH-box helicase 16 / O60231*ENSMUSG0000002442236
Dhx38 / DEAH-box helicase 38 / Q92620*ENSMUSG0000003799336
Dhx15 / O35286 / Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 / O43143* / DEAH-box helicase 15*ENSMUSG0000002916934
Dhx33 / Q80VY9 / Putative ATP-dependent RNA helicase DHX33 / Q9H6R0* / DEAH-box helicase 33*ENSMUSG0000004062032
Dhx35 / probable ATP-dependent RNA helicase DHX35 isoform b / Q9H5Z1* / DEAH-box helicase 35*ENSMUSG0000002765530
Dhx34 / DExH-box helicase 34 / Q14147*ENSMUSG0000000601927
Cltc / Q68FD5 / Mus musculus clathrin, heavy polypeptide (Hc) (Cltc), transcript variant 1, mRNA.ENSMUSG0000004712618


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR007502  Helicase-associated domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR011709  Domain of unknown function DUF1605
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IBA
 cellular_componentGO:0005681 spliceosomal complex IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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