ENSMUSG00000027709


Mus musculus

Features
Gene ID: ENSMUSG00000027709
  
Biological name :Mccc1
  
Synonyms : Mccc1 / Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial / Q99MR8
  
Possible biological names infered from orthology : methylcrotonoyl-CoA carboxylase 1 / Q96RQ3
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: B
Gene start: 35959312
Gene end: 36000678
  
Corresponding Affymetrix probe sets: 10497773 (MoGene1.0st)   1417227_at (Mouse Genome 430 2.0 Array)   1458208_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029259
Ensembl peptide - ENSMUSP00000143396
Ensembl peptide - ENSMUSP00000143266
Ensembl peptide - ENSMUSP00000143039
NCBI entrez gene - 72039     See in Manteia.
MGI - MGI:1919289
RefSeq - NM_023644
RefSeq Peptide - NP_076133
swissprot - A0A0G2JFQ5
swissprot - A0A0G2JF64
swissprot - A0A0G2JG24
swissprot - Q99MR8
Ensembl - ENSMUSG00000027709
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mccc1ENSDARG00000102538Danio rerio
 MCCC1ENSGALG00000008785Gallus gallus
 MCCC1ENSG00000078070Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pcca / Q91ZA3 / propionyl-Coenzyme A carboxylase, alpha polypeptide / P05165* / propionyl-CoA carboxylase alpha subunit*ENSMUSG0000004165037


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR001882  Biotin-binding site
 IPR005479  Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
 IPR005481  Biotin carboxylase-like, N-terminal domain
 IPR005482  Biotin carboxylase, C-terminal
 IPR011053  Single hybrid motif
 IPR011054  Rudiment single hybrid motif
 IPR011761  ATP-grasp fold
 IPR011764  Biotin carboxylation domain
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006552 leucine catabolic process IEA
 cellular_componentGO:0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:1905202 methylcrotonoyl-CoA carboxylase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004075 biotin carboxylase activity IEA
 molecular_functionGO:0004485 methylcrotonoyl-CoA carboxylase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Biotin transport and metabolism
Branched-chain amino acid catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027709 Mccc1 / Q99MR8 / Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial / Q96RQ3* / methylcrotonoyl-CoA carboxylase 1*  / complex
 ENSMUSG00000021646 Mccc2 / Q3ULD5 / Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial / Q9HCC0* / methylcrotonoyl-CoA carboxylase 2*  / complex
 ENSMUSG00000040820 Hlcs / Q920N2 / holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) / P50747* / holocarboxylase synthetase*  / reaction






 

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