ENSMUSG00000041650


Mus musculus

Features
Gene ID: ENSMUSG00000041650
  
Biological name :Pcca
  
Synonyms : Pcca / propionyl-Coenzyme A carboxylase, alpha polypeptide / Q91ZA3
  
Possible biological names infered from orthology : P05165 / propionyl-CoA carboxylase alpha subunit
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: E5
Gene start: 122534324
Gene end: 122891100
  
Corresponding Affymetrix probe sets: 10417183 (MoGene1.0st)   1447577_x_at (Mouse Genome 430 2.0 Array)   1451405_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135557
Ensembl peptide - ENSMUSP00000135266
Ensembl peptide - ENSMUSP00000135665
Ensembl peptide - ENSMUSP00000038763
Ensembl peptide - ENSMUSP00000120027
Ensembl peptide - ENSMUSP00000123422
Ensembl peptide - ENSMUSP00000135087
NCBI entrez gene - 110821     See in Manteia.
MGI - MGI:97499
RefSeq - XM_006518432
RefSeq - NM_144844
RefSeq - XM_006518430
RefSeq Peptide - NP_659093
swissprot - H3BL62
swissprot - D3YZC0
swissprot - D3YWM4
swissprot - Q3UGC8
swissprot - Q91ZA3
swissprot - H3BJR0
swissprot - H3BKW6
swissprot - H3BK61
Ensembl - ENSMUSG00000041650
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pccaENSDARG00000028982Danio rerio
 PCCAENSGALG00000016872Gallus gallus
 PCCAENSG00000175198Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mccc1 / Q99MR8 / Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial / Q96RQ3* / methylcrotonoyl-CoA carboxylase 1*ENSMUSG0000002770937


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR001882  Biotin-binding site
 IPR005479  Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
 IPR005481  Biotin carboxylase-like, N-terminal domain
 IPR005482  Biotin carboxylase, C-terminal
 IPR011053  Single hybrid motif
 IPR011054  Rudiment single hybrid motif
 IPR011761  ATP-grasp fold
 IPR011764  Biotin carboxylation domain
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004075 biotin carboxylase activity IEA
 molecular_functionGO:0004658 propionyl-CoA carboxylase activity IMP
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Biotin transport and metabolism
Propionyl-CoA catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001756 abnormal urination "anomaly in the production and excretion of urine" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002893 ketoaciduria "excretion of urine having an elevated concentration of keto acids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1Amc/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032527 Pccb / Q99MN9 / Propionyl-CoA carboxylase beta chain, mitochondrial / P05166* / propionyl-CoA carboxylase beta subunit*  / complex
 ENSMUSG00000041650 Pcca / Q91ZA3 / propionyl-Coenzyme A carboxylase, alpha polypeptide / P05165* / propionyl-CoA carboxylase alpha subunit*  / complex
 ENSMUSG00000040820 Hlcs / Q920N2 / holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) / P50747* / holocarboxylase synthetase*  / reaction






 

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