ENSMUSG00000032527


Mus musculus

Features
Gene ID: ENSMUSG00000032527
  
Biological name :Pccb
  
Synonyms : Pccb / Propionyl-CoA carboxylase beta chain, mitochondrial / Q99MN9
  
Possible biological names infered from orthology : P05166 / propionyl-CoA carboxylase beta subunit
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E4
Gene start: 100982032
Gene end: 101034898
  
Corresponding Affymetrix probe sets: 10596053 (MoGene1.0st)   1450969_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035116
Ensembl peptide - ENSMUSP00000140354
Ensembl peptide - ENSMUSP00000123421
Ensembl peptide - ENSMUSP00000118006
NCBI entrez gene - 66904     See in Manteia.
MGI - MGI:1914154
RefSeq - XM_006511370
RefSeq - NM_001311149
RefSeq - NM_025835
RefSeq Peptide - NP_001298078
RefSeq Peptide - NP_080111
swissprot - Q99MN9
swissprot - E9Q1J7
swissprot - A0A087WQV1
swissprot - D3YZC1
Ensembl - ENSMUSG00000032527
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pccbENSDARG00000038910Danio rerio
 PCCBENSGALG00000037238Gallus gallus
 PCCBENSG00000114054Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mccc2 / Q3ULD5 / Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial / Q9HCC0* / methylcrotonoyl-CoA carboxylase 2*ENSMUSG0000002164629


Protein motifs (from Interpro)
Interpro ID Name
 IPR000438  Acetyl-CoA carboxylase carboxyl transferase, beta subunit
 IPR011762  Acetyl-coenzyme A carboxyltransferase, N-terminal
 IPR011763  Acetyl-coenzyme A carboxyltransferase, C-terminal
 IPR029045  ClpP/crotonase-like domain superfamily
 IPR034733  Acetyl-CoA carboxylase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0009062 fatty acid catabolic process IBA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0009317 acetyl-CoA carboxylase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003989 acetyl-CoA carboxylase activity IEA
 molecular_functionGO:0004658 propionyl-CoA carboxylase activity ISS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016421 CoA carboxylase activity IBA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
Biotin transport and metabolism
Propionyl-CoA catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nphp1tm1.1(KOMP)Vlcg/Nphp1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nphp1tm1.1(KOMP)Vlcg/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Nphp1tm1.1(KOMP)Vlcg/Nphp1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nphp1tm1.1(KOMP)Vlcg/Ucd

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Nphp1tm1.1(KOMP)Vlcg/Nphp1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nphp1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041650 Pcca / Q91ZA3 / propionyl-Coenzyme A carboxylase, alpha polypeptide / P05165* / propionyl-CoA carboxylase alpha subunit*  / complex
 ENSMUSG00000032527 Pccb / Q99MN9 / Propionyl-CoA carboxylase beta chain, mitochondrial / P05166* / propionyl-CoA carboxylase beta subunit*  / complex
 ENSMUSG00000040820 Hlcs / Q920N2 / holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) / P50747* / holocarboxylase synthetase*  / reaction






 

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