ENSMUSG00000027887


Mus musculus

Features
Gene ID: ENSMUSG00000027887
  
Biological name :Sypl2
  
Synonyms : O89104 / Synaptophysin-like protein 2 / Sypl2
  
Possible biological names infered from orthology : Q5VXT5 / synaptophysin like 2
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.3
Gene start: 108211472
Gene end: 108226648
  
Corresponding Affymetrix probe sets: 10501302 (MoGene1.0st)   1432823_at (Mouse Genome 430 2.0 Array)   1449206_at (Mouse Genome 430 2.0 Array)   1454371_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116756
NCBI entrez gene - 17306     See in Manteia.
MGI - MGI:1328311
RefSeq - NM_008596
RefSeq - XM_006501094
RefSeq Peptide - NP_032622
swissprot - O89104
Ensembl - ENSMUSG00000027887
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sypl2aENSDARG00000055307Danio rerio
 sypl2bENSDARG00000000690Danio rerio
 SYPL2ENSGALG00000032619Gallus gallus
 SYPL2ENSG00000143028Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Synpr / Q8BGN8 / Synaptoporin / Q8TBG9*ENSMUSG0000005629643
Syp / Q62277 / Synaptophysin / P08247*ENSMUSG0000003114441
Sypl / O09117 / synaptophysin-like protein / SYPL1* / Q16563* / synaptophysin like 1*ENSMUSG0000002057035


Protein motifs (from Interpro)
Interpro ID Name
 IPR001285  Synaptophysin/synaptoporin
 IPR008253  Marvel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030285 integral component of synaptic vesicle membrane IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Fgf2tm2Doe/Fgf2tm2Doe
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Sypl2tm1Hta/Sypl2+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Fgf2tm2Doe/Fgf2tm2Doe
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Sypl2tm1Hta/Sypl2+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf2tm2Doe/Fgf2tm2Doe
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf2tm2Doe/Fgf2tm2Doe
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0004088 abnormal sarcoplasmic reticulum morphology "any structural abnormality in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf2tm2Doe/Fgf2tm2Doe
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf2tm2Doe/Fgf2tm2Doe
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0009411 abnormal skeletal muscle fiber triad morphology "any structural anomaly of the skeletal muscle fiber structure comprised of the transverse tubule and the two associated terminal cisternae; each fiber normally has thousands of triads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf2tm2Doe/Fgf2tm2Doe
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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