ENSMUSG00000031144


Mus musculus

Features
Gene ID: ENSMUSG00000031144
  
Biological name :Syp
  
Synonyms : Q62277 / Synaptophysin / Syp
  
Possible biological names infered from orthology : P08247
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.1
Gene start: 7638471
Gene end: 7653256
  
Corresponding Affymetrix probe sets: 10598359 (MoGene1.0st)   1448280_at (Mouse Genome 430 2.0 Array)   1456249_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069429
Ensembl peptide - ENSMUSP00000118544
NCBI entrez gene - 20977     See in Manteia.
MGI - MGI:98467
RefSeq - NM_009305
RefSeq Peptide - NP_033331
swissprot - F6VR28
swissprot - Q62277
Ensembl - ENSMUSG00000031144
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sypaENSDARG00000110528Danio rerio
 sypbENSDARG00000002230Danio rerio
 SYPENSG00000102003Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Synpr / Q8BGN8 / Synaptoporin / Q8TBG9*ENSMUSG0000005629652
Sypl2 / O89104 / Synaptophysin-like protein 2 / Q5VXT5* / synaptophysin like 2*ENSMUSG0000002788734
Sypl / O09117 / synaptophysin-like protein / SYPL1* / Q16563* / synaptophysin like 1*ENSMUSG0000002057033


Protein motifs (from Interpro)
Interpro ID Name
 IPR001285  Synaptophysin/synaptoporin
 IPR008253  Marvel domain
 IPR028714  Synaptophysin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis TAS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IMP
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity IMP
 biological_processGO:0048488 synaptic vesicle endocytosis IMP
 biological_processGO:0071310 cellular response to organic substance IDA
 biological_processGO:2000474 regulation of opioid receptor signaling pathway ISS
 cellular_componentGO:0008021 synaptic vesicle ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030285 integral component of synaptic vesicle membrane TAS
 cellular_componentGO:0030672 synaptic vesicle membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0042734 presynaptic membrane IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0044306 neuron projection terminus IDA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0048786 presynaptic active zone IDA
 cellular_componentGO:0060076 excitatory synapse IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015485 cholesterol binding IEA
 molecular_functionGO:0017075 syntaxin-1 binding ISO
 molecular_functionGO:0042169 SH2 domain binding IDA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

Allelic Composition: Syptm1Leu/Syptm1Leu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002922 decreased post-tetanic potential "reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Itpr1tm1Tno/Itpr1tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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