ENSMUSG00000027905


Mus musculus

Features
Gene ID: ENSMUSG00000027905
  
Biological name :Ddx20
  
Synonyms : Ddx20 / Probable ATP-dependent RNA helicase DDX20 / Q9JJY4
  
Possible biological names infered from orthology : DEAD-box helicase 20 / Q9UHI6
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.2
Gene start: 105678270
Gene end: 105687574
  
Corresponding Affymetrix probe sets: 10500960 (MoGene1.0st)   1416751_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142675
Ensembl peptide - ENSMUSP00000088176
NCBI entrez gene - 53975     See in Manteia.
MGI - MGI:1858415
RefSeq - NM_017397
RefSeq - XM_006501701
RefSeq Peptide - NP_059093
swissprot - A0A0G2JE88
swissprot - Q9JJY4
Ensembl - ENSMUSG00000027905
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx20ENSDARG00000061204Danio rerio
 DDX20ENSGALG00000001504Gallus gallus
 DDX20ENSG00000064703Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ddx39 / Q8VDW0 / ATP-dependent RNA helicase DDX39A / DDX39A* / O00148* / DExD-box helicase 39A*ENSMUSG0000000548117
Ddx39b / Q9Z1N5 / Spliceosome RNA helicase Ddx39b / Q13838* / DExD-box helicase 39B*ENSMUSG0000001943217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000387 spliceosomal snRNP assembly IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048477 oogenesis IMP
 biological_processGO:0050810 regulation of steroid biosynthetic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 cellular_componentGO:0032797 SMN complex IEA
 cellular_componentGO:0034719 SMN-Sm protein complex IEA
 cellular_componentGO:0090571 RNA polymerase II transcription repressor complex IDA
 cellular_componentGO:0097504 Gemini of coiled bodies IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030674 protein binding, bridging IDA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
snRNP Assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002664 decreased circulating adrenocorticotropin level "decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004855 increased ovary weight "greater average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009017 prolonged estrus "increase in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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