ENSMUSG00000028136


Mus musculus

Features
Gene ID: ENSMUSG00000028136
  
Biological name :Snx27
  
Synonyms : Q3UHD6 / Snx27 / Sorting nexin-27
  
Possible biological names infered from orthology : Q96L92 / sorting nexin family member 27
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.1
Gene start: 94497544
Gene end: 94582716
  
Corresponding Affymetrix probe sets: 10499996 (MoGene1.0st)   1430037_at (Mouse Genome 430 2.0 Array)   1433614_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102904
Ensembl peptide - ENSMUSP00000143525
Ensembl peptide - ENSMUSP00000143378
Ensembl peptide - ENSMUSP00000143066
Ensembl peptide - ENSMUSP00000029783
NCBI entrez gene - 76742     See in Manteia.
MGI - MGI:1923992
RefSeq - XM_006502258
RefSeq - NM_001082484
RefSeq - NM_029721
RefSeq Peptide - NP_001075953
RefSeq Peptide - NP_083997
swissprot - Q3UHD6
swissprot - A0A0G2JGD5
swissprot - A0A0G2JF85
swissprot - A0A0G2JG07
Ensembl - ENSMUSG00000028136
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 snx27aENSDARG00000033804Danio rerio
 snx27bENSDARG00000016977Danio rerio
 SNX27ENSGALG00000040687Gallus gallus
 SNX27ENSG00000143376Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Snx31 / Q6P8Y7 / Mus musculus sorting nexin 31 (Snx31), transcript variant 2, mRNA. / Q8N9S9* / sorting nexin 31*ENSMUSG0000001361118
Snx17 / Q8BVL3 / Sorting nexin-17 / Q15036*ENSMUSG0000002914618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR001478  PDZ domain
 IPR001683  Phox homologous domain
 IPR028667  Sorting nexin-27
 IPR029071  Ubiquitin-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008333 endosome to lysosome transport ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport IEA
 biological_processGO:1990126 retrograde transport, endosome to plasma membrane IEA
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030904 retromer complex IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0071203 WASH complex IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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